Self-reported pain was reduced with MT and sham ultrasound treatment 24 hours after treatment, but inflammatory markers within venous circulation and quantitative sensory tests were unable to differentiate between study groups. Therefore, we were unable to characterize mechanisms underlying chronic LBP.
The use of manual therapy in the form of OMT significantly reduced this pilot's pain in three visits and maintained flight status per aeromedical waiver guidelines.
Even with its broad spectrum and low cost, concern over chloramphenicol's adverse effects limited its use in the United States during the 1980s. Reports from United Kingdom and China in the 1990s demonstrated a low incidence of blood dyscrasias with the topical preparation of chloramphenicol, and showed continued good efficacy and low cost. Today, topical chloramphenicol is being used by some groups within otolaryngology and ophthalmology in the United States. As a result, emergency physicians are once again considering chloramphenicol-induced side effects in patients presenting to the emergency department. To date, there have been no published reports associating chest pain, dyspnea with chloramphenicol use, and there has only been one report of fungal esophagitis associated with topical chloramphenicol. We present a 31-year-old woman, 4 months status post tympanoplasty with a modified radical canal wall down mastoidectomy due to a cholesteatoma involving the epitympanum who had a residual tympanic membrane defect. She presented to the emergency department with chest “burning”, with no other symptoms shortly after starting treatment with an insufflated combination antibiotic containing chloramphenicol. After ruling out cardiopulmonary or vascular etiology, she was treated successfully with a gastrointestinal cocktail cocktail for presumed esophagitis secondary to newly prescribed chloramphenicol.
Pb‐induced learning and behavioral deficits, and hypo‐spiny neurons of the motor cortex, cerebellum, and hippocampus, do not occur in rats until blood‐lead levels (BLLs) reach at least 21 μg/dL. In contrast, elevated aggression and poor intelligence scores occur in children with BLLs lower than 10 μg/dL. Similarly, Pb‐exposed kittens show increased aggression with BLLs less than 10 μg/dL, which may be associated with Pb‐induced hyper‐spiny neurons of the motor cortex, hippocampus and cerebellum. These results suggest that Pb ingestion by kittens will result in learning and behavioral deficits similar to those observed in lead‐burdened children. To test this, kittens were treated (20 mg/kg/day, lead acetate or equal volume distilled water via esophageal intubation) from post natal day 1 to 7. At 8‐ and 10‐weeks of age, the kittens were tested in a reversal t‐maze, an open field, and a free fall test. Eight‐week‐old Pb‐treated kittens showed a delay in learning as demonstrated by a significant higher number of incorrect arm choices in the t‐maze that returned to control levels when the kittens reached 10‐weeks of age. No differences occurred between treatment groups at 8‐ and 10‐weeks of age in the open field or free fall tests. These results show the kitten to be a viable model for Pb toxicity studies in that it better simulates the effects of Pb toxicity found in children. Supported by an Institutional Graduate Program Grant.
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