Changes in Cytokines, Sensory Tests, and Self-reported Pain Levels After Manual Treatment of Low Back Pain

Degenhardt, Brian F.; Johnson, Jane C.; Fossum, Christian; Andicochea, Chad T.; Stuart, Melissa K.

doi:10.1097/bsd.0000000000000231

Cited by 29 publications

(39 citation statements)

References 69 publications

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“…[39] Therefore, OMT could reduce the release of cytokines and the sympathetic activity creating a cascade of biological and neurological events able to modulate both inflammatory and ANS mechanisms. [40,41] …”

Section: Discussionmentioning

confidence: 99%

Osteopathic manipulative treatment showed reduction of length of stay and costs in preterm infants

Lanaro

Ruffini²,

Manzotti³

et al. 2017

Medicine

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Background:Osteopathic medicine is an emerging and complementary method used in neonatology.Methods:Outcomes were the mean difference in length of stay (LOS) and costs between osteopathy and alternative treatment group. A comprehensive literature search of (quasi)- randomized controlled trials (RCTs), was conducted from journal inception to May, 2015. Eligible studies must have treated preterm infants directly in the crib or bed and Osteopathic Manipulative Treatment (OMT) must have been performed by osteopaths. A rigorous Cochrane-like method was used for study screening and selection, risk of bias assessment and data reporting. Fixed effect meta-analysis was performed to synthesize data.Results:5 trials enrolling 1306 infants met our inclusion criteria. Although the heterogeneity was moderate (I2 = 61%, P = 0.03), meta-analysis of all five studies showed that preterm infants treated with OMT had a significant reduction of LOS by 2.71 days (95% CI −3.99, −1.43; P < 0.001). Considering costs, meta-analysis showed reduction in the OMT group (−1,545.66€, −1,888.03€, −1,203.29€, P < 0.0001). All studies reported no adverse events associated to OMT. Subgroup analysis showed that the benefit of OMT is inversely associated to gestational age.Conclusions:The present systematic review showed the clinical effectiveness of OMT on the reduction of LOS and costs in a large population of preterm infants.

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Section: Discussionmentioning

confidence: 99%

Osteopathic manipulative treatment showed reduction of length of stay and costs in preterm infants

Lanaro

Ruffini²,

Manzotti³

et al. 2017

Medicine

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“…Moreover, OMT seems to be associated with a reduction of pro-inflammatory substances both in vitro (Meltzer and Standley, 2007 ) and in vivo (Licciardone et al, 2012 , 2013 ) hypothesizing an anti-inflammatory role of OMT, although only partially confirmed by recent clinical-based research (Degenhardt et al, 2014 ).…”

Section: Clinical Applications and Implicationsmentioning

confidence: 98%

Sensitization and Interoception as Key Neurological Concepts in Osteopathy and Other Manual Medicines

2016

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Historically, approaches used in manual medicine to explain patient reported symptoms have been focused on the so-called exteroceptive paradigm. Arguably, this mindset lacks an appropriate "reading system" able to interpret musculoskeletal disorders from a different perspective, where the properties of the nervous system are embraced into a more holistic and functional-related context. Interestingly, if the underpinning mechanisms of a given treatment scenario/effect are taking into account, the majority of research outcomes focuses on a proprioceptive/exteroceptive explanation, leaving ting aside the additional or even central role of interoception. Currently, to date, the application of theoretical knowledge acquired on the relatively recent neuroscientific concepts and evidence concerning of interoception, sensitization, touch, autonomic functions, inflammation, and pain into a clinical/research manual medicine scenario is lacking, even if theoretically, the impact on the possible etiological mechanisms and treatment effects seems to be important. Here, we propose the conceptual foundations for a new way of interpreting and reading patients' clinical reported outcomes scenario based on interoception and sensitization. We argue that this will provide a foundation to create the ground for future research focusing on the hypotheses that manual therapies, specifically osteopathy, can intercede with sensitization states, at all levels, using interoceptive pathways.

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“…Based on the current evidence, it is difficult to identify what are the main neurobiological elements involved during and after administering an osteopathic session. Indeed, it has been suggested that possible OMT mechanisms are modulated by the autonomic nervous system (ANS) functions (Ruffini et al, 2015;D'alessandro et al, 2016), where interoceptive mechanisms might be involved (Cerritelli et al, 2020), leading to a reduction of pro-inflammatory cytokine release (Licciardone et al, 2012;Degenhardt et al, 2017). This evidence was shown both in vitro (Zein-Hammoud and Standley, 2015) and in vivo (Degenhardt et al, 2017), suggesting an anti-inflammatory role of OMT (D'alessandro et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, it has been suggested that possible OMT mechanisms are modulated by the autonomic nervous system (ANS) functions ( Ruffini et al, 2015 ; D’alessandro et al, 2016 ), where interoceptive mechanisms might be involved ( Cerritelli et al, 2020 ), leading to a reduction of pro-inflammatory cytokine release ( Licciardone et al, 2012 ; Degenhardt et al, 2017 ). This evidence was shown both in vitro ( Zein-Hammoud and Standley, 2015 ) and in vivo ( Degenhardt et al, 2017 ), suggesting an anti-inflammatory role of OMT ( D’alessandro et al, 2016 ). McGlone et al (2017) argued that OMT could putatively decrease cytokine production and sympathetic activity, generating a cascade of physiological and neurobiological events, which in turn can modulate the inflammation and the ANS reactivity.…”

Section: Introductionmentioning

confidence: 99%

Does Osteopathic Manipulative Treatment Induce Autonomic Changes in Healthy Participants? A Thermal Imaging Study

Cerritelli¹,

Cardone

Pirino

et al. 2020

Front. Neurosci.

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Osteopathic manipulative treatment (OMT) has been demonstrated to be an effective therapy in several clinical conditions and age groups. Despite the clinical effectiveness, lack of robust data in terms of neurobiological, specifically autonomic, mechanisms of action is observed. Preliminary studies showed a parasympathetic effect leading to a trophotropic effect of OMT. However, these data are limited to heart rate variability (HRV) analysis. In order to study further the role of OMT on the autonomic nervous system, a cross-over randomized controlled trial RCT has been designed to test the effect of osteopathic treatment compared to sham therapy on a range of autonomic parameters. Thermal images, HRV and skin conductance data were collected on a sample of healthy adults. The study design consisted of two sessions (OMT and SHAM), 1 treatment per week, lasting 35 min each, composed of 5 min of baseline, 25 min of treatment, and 5 min of post-touch. During the baseline and the post-treatment, participants received no touch. Thirty-seven participants (aged 27 ± 5 years old, male ratio 40%) completed the study. Multivariate analysis showed a significant parasympathetic effect of group as well as of epoch on thermographic data of the nose (estimate 0.38; 95% CI 0.12-0.63; p < 0.01), left (0.17; 0.06-0.27; <0.001) and right (0.16; 0.07-0.24; <0.001) perioral as well as on the forehead (0.07; 0.01-0.12; <0.01) regions but not for the chin (0.08; −0.02 to 0.18; 0.13). Consistent with a parasympathetic effect, analyses demonstrated a difference between OMT and sham groups on the nuHF (p < 0.001) and DFA-a1 (p < 0.01) as well as on skin conductance (<0.01). The present research supports the hypothesis that a single session of OMT as compared to sham induces autonomic consequences in healthy non-symptomatic adults. Clinicaltrial.gov identifier: NCT03888456, https://clinicaltrials.gov/ct2/show/NCT03888456.

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Changes in Cytokines, Sensory Tests, and Self-reported Pain Levels After Manual Treatment of Low Back Pain

Cited by 29 publications

References 69 publications

Osteopathic manipulative treatment showed reduction of length of stay and costs in preterm infants

Osteopathic manipulative treatment showed reduction of length of stay and costs in preterm infants

Sensitization and Interoception as Key Neurological Concepts in Osteopathy and Other Manual Medicines

Does Osteopathic Manipulative Treatment Induce Autonomic Changes in Healthy Participants? A Thermal Imaging Study

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