Intensive insulin therapy results in a net reduction in microdialysis glucose and an increase in microdialysis glutamate and lactate/pyruvate without conveying a functional outcome advantage.

Objective-To determine whether nonconvulsive electrographic post-traumatic seizures result in increases in intracranial pressure and microdialysis lactate/pyruvate ratio. Design-Prospective monitoring with retrospective data analysis.Setting-Single center academic neurologic intensive care unit.Patients-Twenty moderate to severe traumatic brain injury patients (Glasgow Coma Score 3-13). HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptMeasurements and Main Results-Continuous electroencephalography and cerebral microdialysis were performed for 7 days after injury. Ten patients had seizures and were compared with a matched cohort of traumatic brain injury patients without seizures. The seizures were repetitive and constituted status epilepticus in seven of ten patients. Using a within-subject design, post-traumatic seizures resulted in episodic increases in intracranial pressure (22.4 ± 7 vs. 12.8 ± 4.3 mm Hg; p < .001) and an episodic increase in lactate/pyruvate ratio (49.4 ± 16 vs. 23.8 ± 7.6; p < .001) in the seizure group. Using a between-subjects comparison, the seizure group demonstrated a higher mean intracranial pressure (17.6 ± 6.5 vs. 12.2 ± 4.2 mm Hg; p < .001), a higher mean lactate/pyruvate ratio (38.6 ± 18 vs. 27 ± 9; p < .001) compared with nonseizure patients. The intracranial pressure and lactate/pyruvate ratio remained elevated beyond postinjury hr 100 in the seizure group but not the nonseizure group (p < .02).Conclusion-Post-traumatic seizures result in episodic as well as long-lasting increases in intracranial pressure and microdialysis lactate/pyruvate ratio. Intracranial pressure (ICP) remains one of the principal treatment targets for traumatic brain injury (TBI) (1). Elevation of ICP is due to brain edema, mass effect from hemorrhagic lesions, and possibly from disrupted pressure autoregulation. The treatments for ICP have been focused on these pathophysiologic mechanisms. While the treatment principals for elevated ICP have been codified into guidelines and practiced by many intensivists, ICP often remains refractory to treatment. Indeed, treatment failure resulting in herniation and death occurs frequently. The mechanisms for persistently elevated ICP have not been well elucidated, but candidate mechanisms include sustained hyperemia, excitotoxicity, and osmotic rebound. In contrast, little attention has been paid to the adverse effects of epileptic activity upon the extent or duration of elevated ICP after TBI.In recent years, post-traumatic seizures have been documented to occur frequently after human TBI (2). Indeed, seizures are frequent after a variety of hemorrhagic injuries to the brain (3, 4). The incidence of seizures increases as a function of the severity of injury, and other selected features of the injury such as the presence of hemorrhagic contusions. Posttraumatic seizures previously have been associated with increased glycolysis in both animal and human metabolic imaging studies (5, 6) and have been associated with alterat...

Objective-To determine whether nonconvulsive electrographic post-traumatic seizures result in increases in intracranial pressure and microdialysis lactate/pyruvate ratio. Design-Prospective monitoring with retrospective data analysis.Setting-Single center academic neurologic intensive care unit.Patients-Twenty moderate to severe traumatic brain injury patients (Glasgow Coma Score 3-13).

The CNR of simulated hypervascular liver lesions can be substantially increased and the radiation dose reduced by using an 80-kVp, high tube current CT technique.

No abstract

Frameless stereotactic aspiration and thrombolysis (FAST) of deep spontaneous intracerebral hemorrhage is a safe therapy that is associated with reduction in ICH volume, early improvement in NIHSS and potentially could be used to improve outcome.

Persistent metabolic crisis, as reflected by an elevated lactate/pyruvate ratio, in normal appearing posttraumatic frontal lobe, is predictive of the degree of tissue atrophy at 6 months.

Physicians' diagnoses and admission decisions changed frequently after CT, and diagnostic uncertainty was alleviated.