Traffic congestion plagues cities around the world. Recent years have witnessed an unprecedented trend in applying reinforcement learning for traffic signal control. However, the primary challenge is to control and coordinate traffic lights in large-scale urban networks. No one has ever tested RL models on a network of more than a thousand traffic lights. In this paper, we tackle the problem of multi-intersection traffic signal control, especially for large-scale networks, based on RL techniques and transportation theories. This problem is quite difficult because there are challenges such as scalability, signal coordination, data feasibility, etc. To address these challenges, we (1) design our RL agents utilizing ‘pressure’ concept to achieve signal coordination in region-level; (2) show that implicit coordination could be achieved by individual control agents with well-crafted reward design thus reducing the dimensionality; and (3) conduct extensive experiments on multiple scenarios, including a real-world scenario with 2510 traffic lights in Manhattan, New York City 1 2.

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Successful health risk prediction demands accuracy and reliability of the model. Existing predictive models mainly depend on mining electronic health records (EHR) with advanced deep learning techniques to improve model accuracy. However, they all ignore the importance of publicly available online health data, especially socioeconomic status, environmental factors, and detailed demographic information for each location, which are all strong predictive signals and can definitely augment precision medicine. To achieve model reliability, the model needs to provide accurate prediction and uncertainty score of the prediction. However, existing uncertainty estimation approaches often failed in handling high-dimensional data, which are present in multi-sourced data.To fill the gap, we propose UNcertaInTy-based hEalth risk prediction (UNITE) model. Building upon an adaptive multimodal deep kernel and a stochastic variational inference module, UNITE provides accurate disease risk prediction and uncertainty estimation leveraging multi-sourced health data including EHR data, patient demographics, and public health data collected from the web. We evaluate UNITE on real-world disease risk prediction tasks: nonalcoholic fatty liver disease (NASH) and Alzheimer's disease (AD). UNITE achieves up to 0.841 in F1 score for AD detection, up to 0.609 in PR-AUC for NASH detection, and outperforms various stateof-the-art baselines by up to 19% over the best baseline. We also show UNITE can model meaningful uncertainties and can provide evidence-based clinical support by clustering similar patients.

Small data has been a barrier for many machine learning tasks, especially when applied in scientific domains. Fortunately, we can utilize domain knowledge to make up the lack of data. Hence, in this paper, we propose a hybrid model KRL that treats domain knowledge model as a weak learner and uses another neural net model to boost it. We prove that KRL is guaranteed to improve over pure domain knowledge model and pure neural net model under certain loss functions. Extensive experiments have shown the superior performance of KRL over baselines. In addition, several case studies have explained how the domain knowledge can assist the prediction.