Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and its occurrence is increasing fast in most of the countries. Herbal medicine derived from plant extracts have been utilized increasingly for the treatment of various disorders like diabetes mellitus. The present study was designed to evaluate the antidiabetic activity of Methanolic Extract of Hiptage bengalensis L. Kurz (MEHB) in alloxan induced diabetic rats and chick model. Alloxan (120 mg kg-1) was used to induce diabetes in rats and the blood glucose levels were estimated by using commercial kit in the market. The methanolic extract of Hiptage bengalensis was administered to diabetic rats as single dose for one day at a dose of 100 and 200 mg kg-1. The extract produced a significant reduction (p<0.01) of blood glucose levels at a dose of 100 and 200 mg kg-1 in diabetic rats. It also showed a beneficial effect on the lipid profile in alloxan induced diabetic rats. These results showed that methanolic extract of Hiptage bengalensis produced a dose dependant antihyperglycemic activity in rats.
Phenolic compounds have been the subject of intense research in recent years due to their potential beneficial effects on human health. The phenolic compounds are secondary plant metabolites that are contained within the skin, seed and flesh of grapes and even are extracted into wines (especially red) during the process of vinification 1 . Echinochloa crusgalli Roxb. (Syn: panicum cursgalli linn.) belongs to Gramineae, Poaceae family, distributed throughout tropical Asia and Africa in fields and commonly present in rice fields and moist localities 2 . The plant extract is used in diseases of the spleen. Young shoots are eaten as a vegetable in Java. Reported to be preventative and tonic, barnyard grass is a folk remedy in India for carbuncles, stiffness of lower limbs, ascities, diabetes, sores, spleen trouble, cancer and wounds [3][4][5][6] . It is useful for reclamation of saline and alkaline areas used in diseases of spleen and for checking haemorrhage 7 . The shoots and/or the roots are applied as a styptic to wounds. The plant is a tonic, acting on the spleen 8,9 . High performance thin layer chromatography (HPTLC), highperformance liquid chromatography (HPLC) and LCMSMS are commonly used to determine qualitatively and quantitatively single phenols. All these analytical techniques are often preferred due to sufficient sensitivity and precision. However,
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