Antidiabetic Activity of Methanolic Extract of Hiptage bengalensis Leaves in Alloxan Induced Diabetic Models

Abstract

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and its occurrence is increasing fast in most of the countries. Herbal medicine derived from plant extracts have been utilized increasingly for the treatment of various disorders like diabetes mellitus. The present study was designed to evaluate the antidiabetic activity of Methanolic Extract of Hiptage bengalensis L. Kurz (MEHB) in alloxan induced diabetic rats and chick model. Alloxan (120 mg kg-1) was used to induce diabetes in rats and the blood glucose levels were estimated by using commercial kit in the market. The methanolic extract of Hiptage bengalensis was administered to diabetic rats as single dose for one day at a dose of 100 and 200 mg kg-1. The extract produced a significant reduction (p<0.01) of blood glucose levels at a dose of 100 and 200 mg kg-1 in diabetic rats. It also showed a beneficial effect on the lipid profile in alloxan induced diabetic rats. These results showed that methanolic extract of Hiptage bengalensis produced a dose dependant antihyperglycemic activity in rats.

Antidiabetic potential of ethanolic crude extract of Garcinia atroviridis fruits: in vitro, in ovo, and in silico analysis

“…The in ovo diabetes‐induced chick embryo model was developed by following the method of previous studies (Yoshiyama et al ., 2005; Maheshwari et al ., 2013; Sivajothi & Dakappa, 2014). Briefly, on the 14th day of incubation, fertile eggs were divided into groups (I–VII) and transilluminated to mark the air space area of the embryonated eggs.…”

Hypoglycemic and Hepatoprotective Activities of Coriander (Coriandrum sativum) Extract in Streptozocin Induced Diabetic Rats

“…Bachir and Bellil [97] and Shyamapada and Manisha [98] reported plant containing phytochemicals could be used in preventive strategies to reduce the risk of most diseases including cancer (99Dharmalingam and Nazni 2013). Different kinds of plants have antioxidant substances capable of scavenging free superoxide radicals protecting biological systems against the harmful effects of oxidative processes on macromolecules [12,36]. Recent study has shown that some extracts intake cause improve in some biochemical parameters of oxidative stress and exhibited reduce the risk of some diseases [37,44].…”

“…Administration of some plants significantly diminished the hyperglycemia in mildly diabetic mice [44,90,98]. Other studies reported ten percent of plant extract produced a significant decrease in plasma glucose levels in normal and streptozotocin induced diabetic rats when administered by intraperitoneal injection or gastric tube [4,12,18]. Moreover,, the researchers conducted decades over last has shown plant and plant based therapies have a potential to control and treat diabetes and its complications [82,103].…”

“…A significant decrease in the concentration of plasma glucose was noted after administration of different doses of aqueous and alcoholic extract of different pants [30,33], showed that the aqueous extract contain nearly 50 mg/100g of flavonoids possessed anti hyperglycemic activity [16,51] they proved the insulin-stimulatory effect of Punica granatum, and Syzygium alternifolium from existing β-cells in diabetic rats [8,9,82]. Results showed that the coriander (C. sativum) extract that contain nearly 0.80 g/100g of flavonoids and 4.02g/100g polyphenol possessed anti hyperglycemic activity [9,12,51]. Hence it has proved highly effective in causing significant anti-hyperglycemic response in rats.…”

“…"Chronic inflammation produced from endogenous metabolic processes are consider the most important sources of free radicals react with lipids, proteins, carbohydrates, DNA and damage all types of biomolecules" [7][8][9]. Other studies [10][11][12], indicated "the DM type 2 was increased with oxidative stress resulting oxidative damage of proteins, DNA and lipid associated with chronic degenerative diseases including diabetes, hypertension, coronary heart disease and cancer" [10,11]. Other investigator [11] showed "the free radicals produced may react with polyunsaturated fatty acids in cell membranes leading to lipid peroxidation".…”