The lower stimulation threshold of the adrenals was determined in 104 patients suffering from multiple sclerosis. In another series of patients the effect of insulin induced stress (hypoglycaemia) was surveyed. There was no correlation between the functional state of the adrenals as revealed by the tests and the efficacy of treatment with Cortrosyn. A study comparing the effect of the infusion with physiological doses and the effects of the usually administered therapeutic doses has led to a preference for the first method in the treatment of rapidly progressing cases and for the rapid reduction of functional disturbances linked with organic lesions.
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