A 3D corneal stroma substitute with micro-level patterns was constructed from a stack of 4 micro patterned collagen or collagen-elastin like recombinamer (Col:ELR) blend layers. The transparency of all of the films was quite high with the uncrosslinked (UXL) films and dehydrothermally treated (150 °C, 24 h) Col:ELR films yielding the best results. Human corneal keratocytes (HK) could be attached and proliferated equally well on the single films of Col and Col:ELR. However, for the multilayer constructs the proliferation was higher on Col than on Col:ELR. The cells were found to align along the patterns (microchannels with a 39 μm groove depth, 8 μm groove width, 3.3 μm ridge width, and 54.7° inclination angle) of the films, while no significant alignment was observed on the unpatterned films. The transparency of the seeded Col:ELR films was superior to the Col films over a 30 day incubation period and was quite close to that of a native human cornea. It was concluded that the Col and Col:ELR films and their 3D constructs have significant potential for use as corneal stroma substitutes.
Early diagnosis of diseases leads to choosing an appropriate treatment method and preventing some problems such as drug resistance. It also inhibits the spread of diseases and pandemics in some...
Except for one tropical African species, the Rosa L. species (roses; Rosoideae: Rosaceae) has 150–200 species that are extensively dispersed throughout temperate and subtropical ecosystems of the northern hemisphere. The fact that Central Asia is the rose's native continent is underlined in numerous sources. A quarter of the rose species are found in Europe and North America, while nearly half are found in Asia.
Rosa damascene Mill is the species utilized to obtain rose oil, even though there are 24 types of roses registered in Turkey's flora. Rosa damascene, also referred to as the Damascus Rose, Pink Oil Rose, Oil Rose, and Isparta Rose Rose is a perennial, thorny, intensely perfumed, pink-hued, half-layered, and winter-hardy shrub that only blooms in the spring. The range of products is also increasing due to the demand for roses and rose products in this sector. Many products are being developed in the field of nutrition, cleaning, and cosmetics.
The aim of this study is to investigate the effects of wild rose plants in the field of health and to expand their use. However, it is thought that increasing the variety of products obtained from the wild rose plant may contribute to the country's economy.
The aim of the study is to investigate the use of wild rose plant in our country and in other countries, to show in which diseases it is used and to determine its contribution to the economy of the countries.
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