A review of 3D printing technology for rapid medical diagnostic tools

Shakibania, Sara; Kılıç, Cemile; Ghazanfari, Lida; Tavakoli, Milad; Lee, Ki‐Bum; Khakbiz, Mehrdad

doi:10.1039/d1me00178g

Cited by 11 publications

(8 citation statements)

References 75 publications

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“…This can help make cancer detection more accessible to people in areas with limited resources . 3D printing allows for the rapid and customizable fabrication of complex structures with precise dimensions. ,, This enables the creation of specialized devices specifically designed for cancer detection, such as microfluidic chips or functionalized surfaces for capturing cancer cells . The ability to quickly iterate and optimize the design through 3D printing significantly reduces the development time, leading to faster production and implementation of cancer detectors.…”

Section: What Unique Advantages Are Gained By Using 3d Printing For C...mentioning

confidence: 99%

3D Printing for Cancer Diagnosis: What Unique Advantages Are Gained?

Zhang

2023

ACS Mater. Au

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Cancer is a complex disease with global significance, necessitating continuous advancements in diagnostics and treatment. 3D printing technology has emerged as a revolutionary tool in cancer diagnostics, offering immense potential in detection and monitoring. Traditional diagnostic methods have limitations in providing molecular and genetic tumor information that is crucial for personalized treatment decisions. Biomarkers have become invaluable in cancer diagnostics, but their detection often requires specialized facilities and resources. 3D printing technology enables the fabrication of customized sensor arrays, enhancing the detection of multiple biomarkers specific to different types of cancer. These 3D-printed arrays offer improved sensitivity, allowing the detection of low levels of biomarkers, even in complex samples. Moreover, their specificity can be fine-tuned, reducing false-positive and false-negative results. The streamlined and cost-effective fabrication process of 3D printing makes these sensor arrays accessible, potentially improving cancer diagnostics on a global scale. By harnessing 3D printing, researchers and clinicians can enhance early detection, monitor treatment response, and improve patient outcomes. The integration of 3D printing in cancer diagnostics holds significant promise for the future of personalized cancer care.

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Section: What Unique Advantages Are Gained By Using 3d Printing For C...mentioning

confidence: 99%

3D Printing for Cancer Diagnosis: What Unique Advantages Are Gained?

Zhang

2023

ACS Mater. Au

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“…The ability to produce microelectrodes with customizable shapes and sizes, combined with electronic read-out circuitry, allows for high-resolution, real-time monitoring of electrical signals in the body (Figure ). This can enable early disease detection, leading to early intervention and treatment and improved patient outcomes. − …”

Section: Prospects Of 3d-printed Microelectrodes In Diagnosismentioning

confidence: 99%

Use of 3D Printing Techniques to Fabricate Implantable Microelectrodes for Electrochemical Detection of Biomarkers in the Early Diagnosis of Cardiovascular and Neurodegenerative Diseases

Zilinskaite,

Shukla,

Baradoke

2023

ACS Meas. Sci. Au

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This Review provides a comprehensive overview of 3D printing techniques to fabricate implantable microelectrodes for the electrochemical detection of biomarkers in the early diagnosis of cardiovascular and neurodegenerative diseases. Early diagnosis of these diseases is crucial to improving patient outcomes and reducing healthcare systems' burden. Biomarkers serve as measurable indicators of these diseases, and implantable microelectrodes offer a promising tool for their electrochemical detection. Here, we discuss various 3D printing techniques, including stereolithography (SLA), digital light processing (DLP), fused deposition modeling (FDM), selective laser sintering (SLS), and two-photon polymerization (2PP), highlighting their advantages and limitations in microelectrode fabrication. We also explore the materials used in constructing implantable microelectrodes, emphasizing their biocompatibility and biodegradation properties. The principles of electrochemical detection and the types of sensors utilized are examined, with a focus on their applications in detecting biomarkers for cardiovascular and neurodegenerative diseases. Finally, we address the current challenges and future perspectives in the field of 3D-printed implantable microelectrodes, emphasizing their potential for improving early diagnosis and personalized treatment strategies.

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“…Additive manufacturing (AM) is a flourishing fabrication technique in which intricate three-dimensional (3D) objects are manufactured through the addition of fine successive filaments of materials in a layered manner by computer numerical control (CNC) systems with minimum waste of material and high production flexibility (García-Collado et al, 2022;Tiwary et al, 2022b). Since the emergence of AM as a manufacturing technique in different industrial fields like medical (Savsani et al, 2023;Shakibania et al, 2022;Tiwary et al, 2019), manufacturing tools (Equbal et al, 2022;Lalegani Dezaki et al, 2021; and constructions (Ali et al, 2022;Pajonk et al, 2022), various types of AM processes are evolved to prepare appropriate physical and mechanical characteristics of the manufactured objects. Considering the definite advantages of each strategy, the merits of material extrusion-based (MEX) technique over competing technologies, including low inventory requirements, lowtemperature process and wide spectrum of print materials, confirm the capability of the MEX technique to play an inevitable role in the future of AM technologies (Maidin et al, 2023;Sun et al, 2023;Tiwary and Malik, 2021).…”

Section: Introductionmentioning

confidence: 99%

Additive manufactured parts surface treatment through impinged hot air jet technique the theoretical and experimental evaluation

Barzegar,

Farahani,

Gomroki

2024

RPJ

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Purpose Material extrusion-based additive manufacturing is a prominent manufacturing technique to fabricate complex geometrical three-dimensional (3D) parts. Despite the indisputable advantages of material extrusion-based technique, the poor surface and subsurface integrity hinder the industrial application of this technology. The purpose of this study is introducing the hot air jet treatment (HAJ) technique for surface treatment of additive manufactured parts. Design/methodology/approach In the presented research, novel theoretical formulation and finite element models are developed to study and model the polishing mechanism of printed parts surface through the HAJ technique. The model correlates reflow material volume, layer width and layer height. The reflow material volume is a function of treatment temperature, treatment velocity and HAJ velocity. The values of reflow material volume are obtained through the finite element modeling model due to the complexity of the interactions between thermal and mechanical phenomena. The theoretical model presumptions are validated through experiments, and the results show that the treatment parameters have a significant impact on the surface characteristics, hardness and dimensional variations of the treated surface. Findings The results demonstrate that the average value of error between the calculated theoretical results and experimental results is 14.3%. Meanwhile, the 3D plots of Ra and Rq revealed that the maximum values of Ra and Rq reduction percentages at 255°C, 270°C, 285°C and 300°C treatment temperatures are (35.9%, 33.9%), (77.6%,76.4%), (94%, 93.8%) and (85.1%, 84%), respectively. The scanning electron microscope results illustrate three different treatment zones and the treatment-induced and manufacturing-induced entrapped air relief phenomenon. The measured results of hardness variation percentages and dimensional deviation percentages at different regimes are (8.33%, 0.19%), (10.55%, 0.31%) and (−0.27%, 0.34%), respectively. Originality/value While some studies have investigated the effect of the HAJ process on the structural integrity of manufactured items, there is a dearth of research on the underlying treatment mechanism, the integrity of the treated surface and the subsurface characteristics of the treated surface.

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A review of 3D printing technology for rapid medical diagnostic tools

Abstract: Early diagnosis of diseases leads to choosing an appropriate treatment method and preventing some problems such as drug resistance. It also inhibits the spread of diseases and pandemics in some...

Cited by 11 publications

References 75 publications

3D Printing for Cancer Diagnosis: What Unique Advantages Are Gained?

3D Printing for Cancer Diagnosis: What Unique Advantages Are Gained?

Use of 3D Printing Techniques to Fabricate Implantable Microelectrodes for Electrochemical Detection of Biomarkers in the Early Diagnosis of Cardiovascular and Neurodegenerative Diseases

Additive manufactured parts surface treatment through impinged hot air jet technique the theoretical and experimental evaluation

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