Aim-A case-control study was initiated to determine the risk factors for the development of age related macular degeneration (AMD). Methods-Study 19).Conclusions-This large case-control study confirms some of the risk factors previously identified and may contribute to the determination of methods for prevention of AMD. (Br J Ophthalmol 1998;82:996-1002) Age related macular degeneration (AMD) is the most common cause of blindness in people over 55 years of age in developed countries. The pathogenesis of this condition is still putative 1 and, in absence of therapy, there is a need to identify risk factors associated with AMD in an eVort to preclude its development.Following the Framingham Eye Study, 2 a number of epidemiological studies have attempted to identify risk factors for AMD. 2-23These studies, which were case-control and population based, have provided informative but controversial data. The goals of the present study were to further explore the possible link between environmental factors and systemic and ocular conditions that may be risk factors for AMD in a European population.Based upon previously published reports, we studied the following risk factors in a casecontrol study: present and past smoking habits, coronary artery disease, systemic hypertension, ametropia, iris colour, and lens status.

No abstract

Admixtures stored at 4 degrees C (pH 7.90 +/- 0.004; mean +/- SD) are stable for 48 hours. The CYP and mesna combination can be infused at room temperature over 6 hours without significant degradation of the drugs. Stabilities are dependent on pH, temperature, and/or concentration.