A 31 year old fireman presented with acute pain and tenderness in both shins and forearms. Radiographs were normal but bone scintigraphy showed widespread increased isotope uptake. Serology was consistent with a diagnosis of secondary syphilis, and the patient's symptoms resolved completely six weeks after a course of penicillin.Periostitis is a recognised but rare manifestation of secondary syphilis' and usually occurs in conjunction with other cutaneous and mucosal lesions. We describe a case in which bone pain was the only presenting feature and confirm recent reports of the value of bone scintigraphy in detecting early periostitic lesions.2Case report A 31 year old fireman presented with a two week history of pain in both shins and along the ulnar borders of both forearms. His pain was worse at night, keeping him awake, and his limbs felt tender to touch. He was a sexually active homosexual and had noticed mild anal discomfort for the previous 10 days. He was otherwise well and when directly questioned reported no rashes, eye symptoms, arthralgia, or other orogenital symptoms.On examination he was a fit young man with no rash, mucocutaneous lesions, or lymphadenopathy. He was acutely tender along the anterior borders of both tibiae, and there were 41;# localised areas of tenderness along both ulnae. Rectal examination showed mild proctitis. There was no arthritis and neurological and remaining systemic examination was normal.Routine investigations were normal apart from an erythrocyte sedimentation rate (ESR) of 88 mm in the first hour and an alkaline phosphatase of 1193 IU/l (normal <280
THIS patient, a man aged 45, has very numerous soft fibromata, growing from the skin of the scalp, trunk, and limbs. The tumours, which are all of small size, do not appear to bear any anatomical relationship to the subcutaneous nerves. So far as the patient can remember, the condition commenced to develop some twenty-five years ago and has been steadily progressing ever since. On the outer surface of the right thigh the skin and subcutaneous tissues have become the seat of an enormous pendulous pachydermatocele. It is of interest to note that this is almost completely ancesthetic. In fact, the patient recently pinned a bandage to his tumour, and only discovered the accident two or three days later. There is much patchy pigmentation of the skin, particularly over the abdomen. No intra-abdominal tumours can be detected, and the patient is in good health and suffers no pain.
SIR,-Many of your readers will be aware that a preparatory conference took place in Paris last March which had for its purpose the formation of an international union, whose main objects will be to establish close liaison between organizations concerned in the study of cancer to combat charlatanism; to propose criteria for a unifornm international system of international records; to publish occasional bulletins on matters of international importance ; and to organize future international congresses. The preparatorv conference, which was convened by Monsieur Justin Godart, former Minister of Health, and President d'Honneur of the last International Cancer Congress in Madrid in 1933, was extremely well attended. No fewer than thirty-two countries (twenty European and twelve extra-European) were represented by one or more delegates. The British delegation consisted of Coloinel Smallman from the Ministry of Health; Mr. Richard Davis from the British Empire Cancer Campaign ; Dr. Cramer from the Imperial Cancer Researchl Fund ; Mr. Sampson Handley from the Middlesex Hospital ; and Mr. Cecil Rowntree from the Cancer Hospital. Agreement was reached upon certain general questions of principle, and statutes controlling the organization of the union were adopted.. Of these, the ones relevant to the present purpose are:
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.