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Rowntree, Cecil

doi:10.1259/arr.1909.0059

Cited by 1 publication

(1 citation statement)

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“…Whereas in man after intravenous injection Rowntree and Geraghty 1912) recovered 68 per cent of the injected phenol red in the urine 1 hour after the injection; Shaw (1925) 40 per cent after 15 minutes, 57 per cent after 30 minutes, 69.5 per cent after 1 hour and 74 per cent after 1½ hours; and Chapman and Halsted (1933) 36 per cent after 15 minutes, 54 per cent after 30 minutes, and 66 per cent after 1 hour; we recovered 44 per cent of the injected azofuchsin after 20 minutes, 54 per cent after 30 minutes, 70 per cent after 1 hour, and 75 per cent after l½ hours. Furthermore, as after subcutaneous or intramuscular injection the amount of phenol red excreted in 1 hour was 50 to 51 per cent in man, dogs and rabbits (Rowntree andGeraghty, 1909-10, 1912;Eisenbrey, 1911;Frothingham, Fitz, Folin and Denis, 1913), it appears that the values in man and in rabbits are comparable, which would mean that phenol red and azofuchsin I both have the same excretion curve.…”

Section: Discussionmentioning

confidence: 94%

The Excretion of Cyanol, Azofuchsin I and Water by the Kidneys of Rabbits

Ehrich

Bartol

Wolf

1938

Journal of Experimental Medicine

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In renal disorders function and morphology have not yet been correlated satisfactorily. It is true that the fundamentals have been clarified by the work of Volhard and Fahr; but when we come to details, our knowledge is still incomplete. As recent advances, both in the understanding of renal function and in the experimental production of renal diseases, justified a new attempt in this direction, certain renal disorders have been reproduced, and a comparison of the morphological changes with the changes in function has been made.It may be regarded as definitely established that certain substances are eliminated by the kidneys solely or mainly by filtration through the glomeruli, while others are mainly secreted by the tubules. Therefore, in the present experiments we studied the elimination by the kidneys: (a) of water; (b) of a dye generally regarded as eliminated by glomerular filtration; and (c) of a dye believed to be secreted by the tubular epithelium. While it has often been said that dye tests are of no great value, more recent studies have shown that a properly applied phenol red test, for example, is at least as useful as the urea clearance test (Shaw, 1925;Ockerblad, 1928; Chisholm, 1930;Chapman and Halsted, 1933). Watanabe, Oliver and Addis (1918) appear to have been right when they pointed out that these tests in reality give more than either rate of excretion or blood concentration alone. If the same amount of dye always is injected, the

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Section: Discussionmentioning

confidence: 94%