The antiallodynic effect of tDCS was associated with different neurotransmitters systems; the duration of these after-effects depended on the time exposure to tDCS.
The synthesis and antioxidant, antinociceptive and antiedematogenic activities of sulfonamides derived from carvacrol—a druglike natural product—are reported. The compounds showed promising antioxidant activity, and sulfonamide derived from morpholine (S1) demonstrated excellent antinociceptive and antiedematogenic activities, with no sedation or motor impairment. The mechanism that underlies the carvacrol and derived sulfonamides’ relieving effects on pain has not yet been fully elucidated, however, this study shows that the antinociceptive activity can be partially mediated by the antagonism of glutamatergic signaling. Compound S1 presented promising efficacy and was predicted to have an appropriate medicinal chemistry profile. Thus, derivative S1 is an interesting starting point for the design of new leads for the treatment of pain and associated inflammation and prooxidative conditions.
A planta medicinal Equisetum giganteum tem sido utilizada empiricamente há muito tempo no Brasil para consolidação de fraturas e tratamento da osteoporose, porém, a literatura carece de estudos científicos que comprovem estas atividades. O presente estudo pretende contribuir para o esclarecimento do potencial terapêutico da planta medicinal Equisetum giganteum no reparo ósseo em quadros de osteoporose, por meio de um desenho experimental pré-clínico que investiga aspectos comportamentais, morfológicos e toxicológicos.
A planta medicinal Pterodon pubescens, uma espécie arbórea nativa do cerrado brasileiro conhecida popularmente por sucupira, tem sido utilizada empiricamente há muito tempo para tratamento da osteoporose, porém, a literatura carece de estudos científicos que comprovem esta atividade. O presente estudo pretende contribuir para o esclarecimento do potencial terapêutico da planta medicinal Pterodon pubescens no reparo ósseo em quadros de osteoporose, por meio de um desenho experimental pré-clínico que investiga aspectos comportamentais, morfológicos e toxicológicos.
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