Globally, Invasive Alien Species (IAS) are considered to be one of the major threats to native biodiversity, with the World Conservation Union (IUCN) citing their impacts as 'immense, insidious, and usually irreversible'. It is estimated that 11% of the c. 12,000 alien species in Europe are invasive, causing environmental, economic and social damage; and it is reasonable to expect that the rate of biological invasions into Europe will increase in the coming years. In order to assess the current position regarding IAS in Europe and to determine the issues that were deemed to be most important or critical regarding these damaging species, the international Freshwater Invasives -Networking for Strategy (FINS) conference was convened in Ireland in April 2013. Delegates from throughout Europe and invited speakers from around the world were brought together for the conference. These comprised academics, applied scientists, policy makers, politicians, practitioners and representative stakeholder groups. A horizon scanning and issue prioritization approach was used by in excess of 100 expert delegates in a workshop setting to elucidate the Top 20 IAS issues in Europe. These issues do not focus solely on freshwater habitats and taxa but relate also to marine and terrestrial situations. The Top 20 issues that resulted represent a tool for IAS management and should also be used to support policy makers as they prepare European IAS legislation.

Invasive species management requires allocation of limited resources towards the proactive mitigation of those species that could elicit the highest ecological impacts. However, we lack predictive capacity with respect to the identities and degree of ecological impacts of invasive species. Here, we combine the relative per capita effects and relative field abundances of invader as compared to native species into a new metric, ''Relative Impact Potential'' (RIP), and test whether this metric can reliably predict high impact invaders. This metric tests the impact of invaders relative to the baseline impacts of natives on the broader ecological community. We first derived the functional responses (i.e. per capita effects) of two ecologically damaging invasive fish species in Europe, the Ponto-Caspian round goby (Neogobius melanostomus) and Asian topmouth gudgeon (Pseudorasbora parva), and their native trophic analogues, the bullhead (Cottus gobio; also C. bairdi) and bitterling (Rhodeus amarus), towards several prey species. This establishes the existence and relative strengths of the predator-prey relationships. Then, we derived ecologically comparable field abundance estimates of the invader and native fish from surveys and literature. This establishes the multipliers for the above per capita effects. Despite both predators having known 123Biol Invasions (2017) 19:1653-1665 DOI 10.1007/s10530-017-1378 severe detrimental field impacts, their functional responses alone were of modest predictive power in this regard; however, incorporation of their abundances relative to natives into the RIP metric gave high predictive power. We present invader/native RIP biplots that provide an intuitive visualisation of comparisons among the invasive and native species, reflecting the known broad ecological impacts of the invaders. Thus, we provide a mechanistic understanding of invasive species impacts and a predictive tool for use by practitioners, for example, in risk assessments.

Better international collaboration levels may be needed to tackle the novel and fast growing phenomenon of novel psychoactive drug availability from the web.

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we have been unable to verify that the questionnaires used for online consultations are scrutinised by any healthcare practitioners to determine the appropriateness of the treatment sought. This represents a serious safety concern for UK residents who procure drugs for erectile dysfunction on the internet.

Ireland, being an island situated on Europe's western seaboard, has a fewer number of native species than mainland European Union Member States (MS). Increased numbers of vectors and pathways have reduced the island's biotic isolation, increasing the risk of new introductions and their associated impacts on native biodiversity. It is likely that these risks are greater here than they are in continental MSs, where the native biodiversity is richer. A horizon scanning approach was used to identify the most likely invasive alien species (IAS) (with the potential to impact biodiversity) to arrive on the island of Ireland within the next ten years. To achieve this, we used a consensus-based approach, whereby expert opinion and discussion groups were utilised to establish and rank a list of 40 species of the most likely terrestrial, freshwater and marine IAS to arrive on the island of Ireland within the decade 2017-2027. The list of 40 included 18 freshwater, 15 terrestrial and seven marine IAS. Crustacean species (freshwater and marine) were taxonomically dominant (11 out of 40); this reflects their multiple pathways of introduction, their ability to act as ecosystem engineers and their resulting high impacts on biodiversity. Freshwater species dominated the top ten IAS (seven species out of ten), with the signal crayfish (Pacifastacus leniusculus) highlighted as the most likely species to arrive and establish in freshwaters, while roe deer (Capreolus capreolus) (second) and the warm-water barnacle (Hesperibalanus fallax) (fifth), were the most likely terrestrial and marine invaders. This evidence-based list provides important information to the relevant statutory agencies in both the Republic of Ireland and Northern Ireland to prioritise the prevention of the most likely invaders and aid in compliance with legislation, in particular the EU Regulation on Invasive Alien Species (EU 1143/2014). Targeted biosecurity in both jurisdictions is urgently required in order to manage the pathways and vectors of arrival, and is vital to maintaining native biodiversity on the island of Ireland.

The c-MYC oncogene, containing the DNA 5'-GGAGG repeat sequence, is emerging as an attractive target for anti-cancer therapeutics with evidence to suggest that DNA quadruplex formation is involved in regulating gene transcription. We describe NMR studies and molecular dynamics (MD) simulations on intermolecular quadruplex structures containing the purine-rich GGAGG motif which we show readily assembles to form stable parallel-stranded quadruplexes containing A- and G-tetrads with evidence for weak sequence-specific K(+) ion binding at the 5'-GA step.

OBJECTIVES  The principal aim of this study was to demonstrate the maturation of moral reasoning among pharmacy students as they progress through a 4-year degree programme at a school of pharmacy in the UK. METHODS  The moral reasoning of 332 students from across all 4 years of the Master of Pharmacy (M Pharm) degree, together with 13 faculty members, was assessed using Rest's Defining Issues Test over a 1-week period. KEY FINDINGS  The results demonstrate clear increase moral reasoning scores through all years of study and on into membership of the faculty. This trend was highly significant (t = 7.09; df = 1; P < 0.001). The coefficient of variability (R(2) ) was calculated as 0.92 using linear least squares regression. There was a wide range of moral reasoning scores at each educational level: the top 18% of the Level 1 cohort achieved higher scores than the bottom 11% of faculty. CONCLUSIONS  The students at a school of pharmacy at a UK university experienced significant moral growth throughout the course of their studies. A further, longitudinal study of the cohort, which attempts to correlate the moral development with age, sex, level of education and mode of delivery of moral education is warranted.