Broth filtrate of a Vibrio species, isolated from spontaneously occurring epizootics among cultured oyster larvae, Crassostrea virginica (Gmelin), was shown to contain an exotoxin. Bioassays demonstrated that LCao value was less than 46-6 /xg of toxin/1 culture of oyster embryos. This quantity was produced by 2-9 X 10^ colony-forming units. Purified toxin showed neither proteolytic nor amylase activity; it did, however, demonstrate bacteriostatic capability. Studies showed that the toxin was heat-labile and that exposure to heat-produced toxoid had a beneficial effect on oyster embryonic development. Data revealed that although toxin was inactivated by heating, the bacteriostatic capability of the metabolite^wasTToF lost.TvTotecalgx weight of the toxin was estimated to be 68 000.
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