No abstract

Cystic fibrosis and celiac disease were considered a single clinical entity for many years. Differentiation between the diseases occurred some time in the 1930s of the 20th Century. Both diseases may present the intestinal malabsorption syndrome and similar clinical manifestations that contribute to difficulties with clinical distinction. We describe a report of two patients with initial diagnosis of cystic fibrosis, who were subsequently diagnosed with celiac disease. These case reports emphasize the possibility of false positivity being shown in the sweat test in CD, which may result in delayed diagnosis and inadequate management of this disease.

No abstract

No abstract

Background: Consumption of nutrients such as docosahexaenoic acid (DHA), prebiotics, and beta‐glucan have been associated with a decrease in the occurrence of allergic manifestations (AM). Objective: To assess if consumption of a follow‐up formula with these and other essential nutrients would affect incidence of AM in children. Methods: In this double‐blind, randomized, controlled trial, healthy 1‐4 year old children from 2 daycare centers in Brazil were fed 3 servings/day of a cow’s milk‐based follow‐up formula with DHA, prebiotics polydextrose (PDX) and galactooligosaccharides (GOS), and beta‐glucan (FF; n=125), or an unfortified cow’s milk‐based beverage (C; n=131) for up to 28 weeks. Occurrence of AM was assessed by study pediatricians and analyzed by the Cochran‐Mantel‐Haenszel test and the counting process of Andersen‐Gill. Results: The FF group had fewer episodes of AM, which included allergic rhinitis, conjunctivitis, wheezing, allergic cough, eczema, and urticaria (Table) and a lower hazard ratio for having AM (HR, 0.64; 95% CI 0.47‐0.89; p=0.007). Conclusions: A cow’s milk‐based formula with added DHA, PDX, GOS, and beta‐glucan and fortified with micronutrients including zinc, vitamin A, and iron, when consumed 3 times per day for 28 weeks by 1‐4 year old children, was associated with fewer allergic manifestations in the skin and the respiratory tract.

No abstract

Objective: Report of two cases of patients with cystic fibrosis (CF), in a multidisciplinary pediatric service in Salvador-BA, which showed early liver involvement. Description of cases: Case 1: Child, female, 23 months of age, diagnosed with CF after repeated respiratory infections during the first month of life, with airway colonization with Pseudomonas aeruginosa and important nutritional impairment. During hospitalization, it was identified hepatomegaly with increased hepatic canaliculary enzymes and aminotransferases, and imaging studies suggesting chronic liver disease. It was conducted genetic study and it was detected a homozygous DF508 mutation. Case 2: Child, female, 7 years of age, presented hepatointestinal form of CF, with histological diagnosis of cirrhosis at 3 years of age and esophageal varices at 5 years without respiratory manifestations of CF, but with nutritional deficits. It has been conducted genetic study which detected mutations DF508 and G542X. Comments: These reported cases are distinguished by early manifestations of liver and also the severity, progression and chronicity of the disease in one of them, revealing the importance of including FC in the differential diagnosis of liver disease, regardless of age, even in the absence of pulmonary disease. These cases must also alert to the importance of periodic screening for liver disease in all patients with CF.

No abstract