Background: Consumption of nutrients such as docosahexaenoic acid (DHA), prebiotics, and beta‐glucan have been associated with a decrease in the occurrence of allergic manifestations (AM). Objective: To assess if consumption of a follow‐up formula with these and other essential nutrients would affect incidence of AM in children. Methods: In this double‐blind, randomized, controlled trial, healthy 1‐4 year old children from 2 daycare centers in Brazil were fed 3 servings/day of a cow’s milk‐based follow‐up formula with DHA, prebiotics polydextrose (PDX) and galactooligosaccharides (GOS), and beta‐glucan (FF; n=125), or an unfortified cow’s milk‐based beverage (C; n=131) for up to 28 weeks. Occurrence of AM was assessed by study pediatricians and analyzed by the Cochran‐Mantel‐Haenszel test and the counting process of Andersen‐Gill. Results: The FF group had fewer episodes of AM, which included allergic rhinitis, conjunctivitis, wheezing, allergic cough, eczema, and urticaria (Table) and a lower hazard ratio for having AM (HR, 0.64; 95% CI 0.47‐0.89; p=0.007). Conclusions: A cow’s milk‐based formula with added DHA, PDX, GOS, and beta‐glucan and fortified with micronutrients including zinc, vitamin A, and iron, when consumed 3 times per day for 28 weeks by 1‐4 year old children, was associated with fewer allergic manifestations in the skin and the respiratory tract.
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