The aim of this study was to evaluate the ability of topical tacrolimus 0.1% under occlusion for 48 h to suppress nickel-elicited allergic contact dermatitis in a randomized, petrolatum- and mometasone furoate 0.1% ointment-controlled double-blind, intra-individual study which included 28 women volunteers. 3 closed patch tests (Finn Chambers on Scanpor, Epitest Ltd Oy, Tuusula, Finland) containing 0.1 ml of 5% nickel sulfate in petrolatum were applied on day 0. After removal on day 2, the study compounds were applied under occlusion for 48 h. The eczema reaction and the degree of erythema were evaluated clinically and by reflectance spectrophotometry at days 4 and 7, respectively. Mean visual scores corresponding to petrolatum-treated sites were significantly higher than those corresponding to both mometasone furoate and tacrolimus at days 4 (P < 0.001) and 7 (P < 0.001). In both tacrolimus- and mometasone furoate-treated sites, there was a significant decrease in visual scores with time (P < 0.001) from day 2 to day 7, and the corresponding mean decreases in scores were 0.73 and 1.04, respectively. The difference between both was 0.30 in favour of tacrolimus (95% confidence intervals, -0.04 and 0.65), although this did not reach statistical significance (P = 0.084). Mean erythema index values were similar at day 2. Significant differences among treatment sites were seen at days 4 (P < 0.001) and 7 (P < 0.001). The decrease was significantly more pronounced on day 7 in patches where tacrolimus had been supplied (P < 0.5). This method might provide useful means to compare different concentrations and/or presentations of tacrolimus or other calcineurin inhibitors and topical anti-inflammatory agents.
Context: In recent years, the qualitative research on empirical software engineering that applies Grounded Theory is increasing. Grounded Theory (GT) is a technique for developing theory inductively e iteratively from qualitative data based on theoretical sampling, coding, constant comparison, memoing, and saturation, as main characteristics. Large or controversial GT studies may involve multiple researchers in collaborative coding, which requires a kind of rigor and consensus that an individual coder does not. Although many qualitative researchers reject quantitative measures in favor of other qualitative criteria, many others are committed to measuring consensus through Inter-Rater Reliability (IRR) and/or Inter-Rater Agreement (IRA) techniques to develop a shared understanding of the phenomenon being studied. However, there are no specific guidelines about how and when to apply IRR/IRA during the iterative process of GT, so researchers have been using ad hoc methods for years. Objective: This paper presents a process for systematically applying IRR/IRA in GT studies that meets the iterative nature of this qualitative research method, which is supported by a previous systematic literature review on applying IRR/RA in GT studies in software engineering. This process allows researchers to incrementally generate a theory while ensuring consensus on the constructs that support it and, thus, improving the rigor of qualitative research. Method: Meta-science guided us to analyze the issues and challenges of the GT method when various raters are involved in coding procedures and formalize a process to improve collaborative team science and consortia. Results: This process formalization helps researchers to apply IRR/IRA to GT studies when various raters are involved in coding. Measuring consensus among raters promotes communicability, transparency, reflexivity, replicability, and trustworthiness of the research. Conclusions: The application of this process to a GT study seems to support its feasibility. In the absence of further confirmation, this would represent the first step of a de facto standard to be applied to those GT studies that require IRR/IRA.
Multilingual lexicons are needed in various applications, such as cross-lingual information retrieval, machine translation and some others. Often, these applications suffer from the ambiguity of dictionary items, especially when an intermediate natural language is involved in the process of the dictionary construction, since this language adds its ambiguity to the ambiguity of working languages. This paper aims at proposing a new method for producing multilingual dictionaries without the risk of introducing additional ambiguity. As a disambiguated intermediate language we use the so-called Universal Words. A set of more than 200,000 unambiguous Universal Words have been constructed automatically on the basis of the well-known English lexical database WordNet. This approach is being used for the construction of a five language-dictionary in the field of cultural heritage within the framework of the PATRILEX project sponsored by the Spanish Research Council.
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