Dermato myofibroma is included in the group of benign cutaneous mesenchymal neoplastic lesions of fibroblastic and myofibroblastic lineage. It's a rare disease and there are approximately only one hundred cases described worldwide in the medical literature up to now. The present study reports the case of a young woman with typical clinical cutaneous lesion and histopathological diagnosis of dermato myofibroma. Special stains were carried out which showed preserved collagen fibers and immunohistochemistry was positive for vimentin and negative for actin and S100. As it is a rare disease, the histopathological findings are of great importance but clinical suspicion is possible in typical cases such as this one.
Dowling-Degos disease (DDD) is a rare genetic disease of the skin (reticulate pigmented anomaly), clinically characterized by flexural brown pigmented reticulate macules, comedo-like papules on the back, neck and pitted perioral or facial scars. We present the case of a 51 year-old man with macrocomedo-like lesions, pitted scars, cysts, hyperpigmented macules in his back, chest, axillae, neck, groin and face. The patient reported having two children, three brothers and a father with a similar condition. The histopathology of the skin biopsies was very characteristic of Dowling-Degos disease, showing dilated follicular, fingerlike projections called rete ridges (dermal pegs), with thinning of the suprapapillary plates, resulting in an "antler-like" pattern and increased pigmentation of the basal layer. Keywords: Hyperpigmentation; Keratin-5; Skin diseases, genetic Resumo: A doença de Dowling-Degos é uma genodermatose rara que consiste numa desordem pigmentar reticulada. Caracteriza-se pela presença de máculas hiperpigmentadas nas regiões flexurais com distribuição em rede; lesões tipo comedão no dorso e na região cervical; e cicatrizes cribriformes na face, particularmente periorais. Apresentamos um caso de um paciente de 51 anos, masculino, com lesões tipo macrocomedões, cicatrizes cribriformes, cistos e máculas hipercrômicas no dorso, tórax anterior, axilas, pescoço, região genital e face. Relatava ter dois filhos, três irmãos e o pai com quadro semelhante. As biópsias de pele foram características da doença de Dowling-Degos, mostrando dilatação folicular, epiderme digitiforme, com áreas de aspecto de "chifre de veado" e focos de hiperpigmentação da camada basal.
Cyclosporine has been con train di ca ted in patients with chro nic infec tions such as infec tion with hepa ti tis C becau se of its immu no sup pres si ve effect. Recent stu dies have shown howe ver that cyclos po rine sup pres ses viral repli ca tion and thus can not exa cer ba te infec tion with hepa ti tis C when emplo yed for trea ting patients with pso ria sis. We pre sent the case of a fema le patient with pso ria sis for 30 years and hepa ti tis C for 20 years, with dif fu se cir ci na te lesions. Improvement in the skin con di tion and liver enzymes was obtai ned with the use of cyclos po ri ne, with no adver se effect. Keywords: Cyclosporine; Hepatitis C; Psoriasis Resumo: A ciclos po ri na tem sido con train di ca da nos pacien tes com infec ções crô ni cas, como a infec ção pelo vírus da hepa ti te C, devi do ao seu efei to imu nos su pres sor. No entan to, estu dos recen tes têm demonstra do que a ciclos po ri na supri me a repli ca ção viral e pode, desta forma, não exa cer bar a infec ção pelo vírus da hepa ti te C, quan do admi nis tra da como tra ta men to para pacien tes com pso ría se. Apresentamos o caso de uma pacien te por ta do ra de pso ría se há 30 anos e hepa ti te C há 20 anos, com lesões cir ci na das difu sas, que apre sen tou melho ra cutâ nea e das enzi mas hepá ti cas com o uso da ciclos po ri na, sem apre sen tar nenhum efei to adver so.
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