Chagas infection is a major endemic disease affecting Latin American countries. The persistence of Trypanosoma cruzi generates a chronic inflammatory reactivity that induces an immune response directed to the host's tissues. The effectiveness of the treatment in the chronic phase is still unsatisfactory due, amongst other reasons, to the collateral effects of the drugs used. We investigated the effect of clomipramine, a tricyclic antidepressant that, when used as a treatment of T. cruzi-chronically infected mice, inhibits trypanothione reductase, an exclusive and vital enzyme of T. cruzi. Clomipramine improved survival (P<0.05) by diminishing the parasite intensity as demonstrated by PCR studies in the heart and skeletal muscle, and significantly prevented the evolution to fibrosis of the inflammatory infiltrates. Clomipramine could be a good candidate for the treatment of chronic Chagas disease.
Los cabestrillos utilizados actualmente no han incorporado innovaciones significativas en lo que respecta a los materiales de confección. Indudablemente hay carencia de alternativas puestas a prueba que superen los materiales que actualmente se encuentran en uso, pero ello no quiere decir que éstos sean inmejorables.Este trabajo se sostiene en la convicción de que un grupo de trabajo interdisciplinario produce frutos innovadores. Es por ello que aquí, especialistas de distintas disciplinas se proponen el desarrollo de materiales y tecnologías que aporten soluciones eficientes para el mejoramiento de este producto de apoyo (PA) para esta patología específicamente.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.