Lysine is a precursor for the synthesis of an aminobutyl C-functionalised tetra-azacyclododecane tetra-acid which has been linked to 872.3 antibody and may be labelled with 9OY to form a kinetically stable complex of potential use in radio i m mu not h e ra py .
Tetra-aza-macrocycles covalently attached to a monoclonal anti body may be efficiently radiolabelled with 64Cu or 67Cu at pH 4, minimising non-specific binding to the protein, giving a kinetically stable conjugate in vivo.
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