Towards tumour targeting with copper-radiolabelled macrocycle–antibody conjugates

Morphy, J. Richard; Parker, David; Kataky, Ritu; Harrison, A.; Eaton, Michael A. W.; Millican, Andrew T.; Phipps, Alison; Walker, Carole A.

doi:10.1039/c39890000792

Cited by 36 publications

(41 citation statements)

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“…These features have been harnessed to develop macrocycles able to transport radioisotopic agents to a tumour site ( 64 Cu and 67 Cu for example). [2] Moreover, changes in the nitrogen (or carbon) substitution can determine their potential applications. In particular, functionalisation of cyclen by substituents such as acetate binding arms has led to a new class of ligands which are able to coordinate lanthanide cations especially Gd III .…”

Section: Introductionmentioning

confidence: 99%

Spectroscopy and Redox Behaviour of Dicopper(II) and Dinickel(II) Complexes of Bis(cyclen) and Bis(cyclam) Ligands

et al. 2005

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The dinuclear CuII and NiII complexes of meta‐xylyl and pyridyl biscyclen and biscyclam have been prepared and characterised in solution by means of UV/Visible spectra, electrochemical and EPR studies. X‐ray structures of copper biscyclen complexes have been obtained. The comparison of all the data shows that the potentially coordinating N(py) pyridyl atom promotes the interaction between the two metal centers, whether it is spontaneously coordinated (biscyclen complexes) or not (biscyclam ones). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

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Section: Introductionmentioning

confidence: 99%

Spectroscopy and Redox Behaviour of Dicopper(II) and Dinickel(II) Complexes of Bis(cyclen) and Bis(cyclam) Ligands

et al. 2005

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“…Mouse antibody 7-6C1 against TIMP-1 was purchased from Oncogene Science. The metalloprotease inhibitor CT1847 (20) was kindly provided by A. Docherty (Celltech, Slough, U.K.).…”

Section: Methodsmentioning

confidence: 99%

Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion

Nakahara

Howard

Thompson

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

373

306

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“…[40b] viewed as good chelating agent which may have utility in NMR imaging, [33] and in biological screenings. [34] The α-Furthermore, benzaldehyde reacts differently with phosaminophosphonate analogs have been recently de-phane (PH 3 ) in alcoholic solution and affords bis(α-ethoxyscribed.…”

Section: Synthesis Of α-Hydroxyalkylphosphinic Acidsmentioning

confidence: 99%

Phosphorylating Power of Red Phosphorus towards Aldehydes in Basic and in Acidic Media

Albouy¹,

Etemad‐Moghadam²,

Koenig³

1999

Eur. J. Org. Chem.

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The reactivity of red phosphorus towards aldehydes was investigated under basic and acidic media. It was demonstrated that the real phosphorylating agent involved in the reaction was phosphane (PH3) in basic media, and hypophosphorous acid (H3PO2) in acidic media. A convenient one‐pot synthesis of (α‐hydroxyalkyl)phosphinic acids from red phosphorus and aldehydes in basic media was realized under sonication. The same reaction under acidic media in the presence of hydriodic acid led to the corresponding phosphonic acids. The (α‐hydroxyalkyl)phosphinic acids were readily prepared under sonication from hypophosphorous acid and aldehydes in the presence of catalytic amounts of hydrochloric acid. The mechanism of the addition reaction of PH3 to benzaldehyde was elucidated and shows the complexity of the reaction as a function of the experimental conditions.

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Towards tumour targeting with copper-radiolabelled macrocycle–antibody conjugates

Abstract: Tetra-aza-macrocycles covalently attached to a monoclonal anti body may be efficiently radiolabelled with 64Cu or 67Cu at pH 4, minimising non-specific binding to the protein, giving a kinetically stable conjugate in vivo.

Cited by 36 publications

References 1 publication

Spectroscopy and Redox Behaviour of Dicopper(II) and Dinickel(II) Complexes of Bis(cyclen) and Bis(cyclam) Ligands

Spectroscopy and Redox Behaviour of Dicopper(II) and Dinickel(II) Complexes of Bis(cyclen) and Bis(cyclam) Ligands

Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion

Phosphorylating Power of Red Phosphorus towards Aldehydes in Basic and in Acidic Media

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