We describe a case of Pediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in an 8-year-old child. The patient developed multiorgan dysfunction, including mixed shock, cardiac dysfunction with myocarditis, pneumonia, acute kidney failure, and gastrointestinal involvement characterized by inflammation of the wall of the bowel and pancreatitis. After treatment with Tocilizumab and corticoid therapy, he presented clinical improvement and normalization of inflammatory markers. PIMS-TS is a new disease developed in a small percentage of patients, so a high degree of suspicion is necessary to establish the diagnosis. Supportive care is of paramount importance. The use of Tocilizumab to control the inflammatory response is likely to be beneficial, but the best immunotherapeutic agent has not yet been established. Randomized clinical studies should be run to determine the best treatment.
Dog bites are a common event, especially in the pediatric population. Common anatomic site of dog bites is the head. Despite this, intracranial injuries due to dog bites are reported anecdotally, especially in neonates. We report a 7-day-old female neonate attacked in the head by the family dog. She presented penetrating bilateral intracranial injuries that required urgent surgery and pediatric intensive care unit (PICU) admission. She received rabies and tetanus prophylaxis, wide-spectrum antibiotic, and anticonvulsive prophylaxis. She was hospitalized in PICU for 9 days, developing intracranial hypertension. One year after the dog bite, she showed moderate psychomotor retardation and focal epilepsy.
Objetivo: Describir una cohorte de pacientes adultos críticos con COVID-19, ingresados en una Unidad de Cuidados Intensivos Pediátrica manejada por pediatras intensivistas (UCI-MP).Pacientes y Método: Estudio observacional retrospectivo de adultos ingresados en UCI-MP por COVID-19 del 11 de mayo al 26 de julio de 2020. Se registraron datos demográficos, clínicos, bioquímicos, características del soporte ventilatorio y complicaciones. La gravedad de la enfermedad se caracterizó por el puntaje en el “Acute Physiology and Chronic Health Evaluation II score” (APACHE II) utilizando datos de las primeras 24 horas de ingreso a la UCI-MP.Resultados: Noventa y tres pacientes mayores de 18 años con COVID-19 sospechado o confirmado ingresaron en la UCI-MP. La media de edad fue de 60,3 años (DE 13,9) y 59 pacientes (63,4%) eran varones. Ochenta y dos pacientes (88,1%) tenían al menos una comorbilidad médica. La puntuación media de APACHE II fue de 9,4 puntos (DE 5,6). Cincuenta y un pacientes (54,8%) fueron ventilados de forma invasiva, durante una mediana de 13,7 días (DE 17,9). Se utilizó soporte inotrópico en 45 pacientes (48%). Treinta y tres pacientes (35,5%) presentaron falla renal aguda (FRA) y 14 (15,1%) recibieron terapia de reemplazo renal continua. Veintinueve pacientes (31,2%) tuvieron infecciones asociadas a la asistencia sanitaria. La estancia media en UCI-MP fue de 10,8 días (DE 11,8). Murieron 25 pacientes (26,9%). En 10 (40%) de los 25 pacientes que fallecieron, se estableció adecuación del esfuerzo terapéutico.Conclusiones: La tasa de mortalidad de los pacientes críticamente enfermos con COVID-19 es alta. Los pacientes de edad avanzada (> 70 años), los que requieren ventilación mecánica invasiva y los que desarrollan FRA tienen un mayor riesgo de muerte. Aunque no se trata de un estudio comparativo, la tasa de mortalidad y complicaciones de este estudio parecen ser similares a las reportadas en las series de casos de pacientes manejados por intensivistas de adultos.
Most children and adolescents with SARS-CoV-2 infection show no or mild symptoms, but those with medical histories can be susceptible to more severe forms of disease. There are few reported cases of extracorporeal membrane oxygenation (ECMO) in pediatric patients with coronavirus disease 2019 (COVID-19). We present a previously healthy 13-year-old male diagnosed with metastatic Ewing’s sarcoma at the same time as catastrophic acute respiratory distress syndrome due to COVID-19, who was successfully supported by venovenous-ECMO while he received the corresponding chemotherapy protocol. ECMO can be used as salvage therapy in oncology pediatric patients with respiratory failure secondary to COVID-19. In addition, successful chemotherapy can be administered while patients are supported on ECMO.
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