The past few decades have shown a worrisome increase in the prevalence of obesity and its related illnesses. This increasing burden has a noteworthy impact on overall worldwide mortality and morbidity, with significant economic implications as well. The same trend is apparent regarding pediatric obesity. This is a particularly concerning aspect when considering the well-established link between cardiovascular disease and obesity, and the fact that childhood obesity frequently leads to adult obesity. Moreover, most obese adults have a history of excess weight starting in childhood. In addition, given the cumulative character of both time and severity of exposure to obesity as a risk factor for associated diseases, the repercussions of obesity prevalence and related morbidity could be exponential in time. The purpose of this review is to outline key aspects regarding the current knowledge on childhood and adolescent obesity as a cardiometabolic risk factor, as well as the most common etiological pathways involved in the development of weight excess and associated cardiovascular and metabolic diseases.
In this study, more than half of the patients chronically infected with the hepatitis C virus, who had hepatic cytolysis and were treated with simvastatin, showed a significant reduction in the level of viremia.
Summary
The process of cytodifferentiation in spermatogenesis is governed by a unique genetic and molecular programme. In this context, accurate ‘tuning’ of the regulatory mechanisms involved in germ cells differentiation is required, as any error could have dramatic consequences on species survival and maintenance. To study the processes that govern the spatial–temporal expression of genes, as well as analyse transmission of epigenetic information to descendants, an integrated approach of genetics, biochemistry and cytology data is necessary. As information in the literature on interplay between DNA methylation and histone H3 lysine 4 trimethylation (H3K4me3) in the advanced stages of murine spermatogenesis is still scarce, we investigated the effect of a DNA methyltransferase inhibitor, 5-aza-2′-deoxycytidine, at the cytological level using immunocytochemistry methodology. Our results revealed a particular distribution of H3K4me3 during sperm cell differentiation and highlighted an important role for regulation of DNA methylation in controlling histone methylation and chromatin remodelling during spermatogenesis.
In this paper are highlighted the stresses that appear in the peri-implantation area through the forces induced by the masticatory process. The analysis consists of computer modeling of the dental implant and simulation of the load with a distributed force. It is considered a variable direction loading related to the axial insertion of the dental implant, thus simulating an important masticatory process. This type of load reveals stresses developed in the periimplantary bone area, the risk areas where the stresses can cause the appearance of hard tissue damage near the implant and its failure. Increases in stresses up to 159% in the ruminant type of chewing compared with the cutter type are highlighted. An aggravating factor that can lead to implant failure is bruxism that tangentially stresses the implant leading to the concentration of forces at the abutment-implant junction. Conclusions regarding the decrease of stresses at bone-implant junction with up to 23% by a corresponding increase of the implant diameter by 25% are also issued.
Nursing theories have been developed to provide guidance in clinical practice, so their knowledge by nurses is mandatory in order to provide advanced nursing care. This paper presents the relationships between the concepts and major assumptions of Henderson’s model and Orem’s theory and then their comparative analysis. Both, Henderson’s model and Orem’s theory of self-care deficit have a major impact, internationally, in education and research, but also in nursing practice, as a result of which their knowledge can open a new perspective on care, especially in countries where they are not well enough known.
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