Eunicea fusca. -A new diterpene, fuscoside E (I), is isolated along with two known fuscosides, (+)-germacrene and a mixture of six known sterols from the Caribbean octocoral Eunicea fusca. The new diterpene (I) and one of the known fuscosides show strong anti-inflammatory activity. Additionally, the new diterpene (I) and the sterol mixture present antifouling activity against bacterial strains involved in surface colonization. -(REINA, E.; PUENTES, C.; ROJAS, J.; GARCIA, J.; RAMOS*, F. A.; CASTELLANOS, L.; ARAGON, M.; OSPINA, L. F.; Bioorg. Med. Chem. Lett. 21 (2011) 19, 5888-5891, http://dx.
Habitually, control of biological fouling includes application of paints containing toxic substances that end upcontaminating marine ecosystem. Many organisms prevent settlement of other species synthesizing secondarymetabolites that could be used in the elaboration of environmentally friendly anti-fouling paints. This work evaluated the behavior of anti-fouling paints based on extracts from marine invertebrates in the ColombianCaribbean: Agelas tubulata, Myrmekioderma gyroderma, Oceanapia peltata, Aplysina lacunosa, Neopetrosia próxima,and Holothuria glaberrima. The painted panels were submerged in the port of Mar del Plata (Argentina); after 90 days in the sea signi!cant differences were registered in the total coverage between the painted panels andthe controls (p<0.05). The results obtained represent important progress toward using natural compounds incontrolling encrustations.
Marine Natural Products (MNPs) isolated from samples collected in Colombia have been an object of study since the early 1980's; however, this information is neither integrated nor compiled. This systematic review describes the articles published in scientific journals up to December 2019. 173 papers met the inclusion criteria of focusing on MNPs obtained from specimens collected from Colombian seas; all original papers written in English, Portuguese or Spanish. The selected papers were mostly authored by researchers from Colombian groups, with low interaction amongst themselves. 99.4% of the papers studied samples collected from the Caribbean Sea; 183 species were studied, mainly sponges and octocorals. In this study, 1,690 compounds (238 new ones) were reviewed, mainly diterpenes and sterol derivatives. Of the selected papers, 76.8% measured various biological activities, including antibiotic (34%) and anticancer (30%). These papers were published in 51 journals (74.6% were international). In conclusion, scientific work on natural marine products of Colombian origin has incremented over time. The most relevant opportunities to address and fill existing gaps comprise: exploring Pacific Ocean organisms and several of the misrepresented taxa; promoting strong interactions amongst the MNPs research groups, and accordingly with other areas of knowledge; and having the productive sector participate in MNPs research.
Identification of bioactive metabolite cell producers allow driving cell culture experiments for in vitro production, just as elucidation of the possible physiologic function of metabolites. The Caribbean marine sponge Discodermia dissoluta produces the polyketide (+)-discodermolide, a potent antitumoral that has reached clinic trials in humans. In this research, progress was made in identifying the producing cells by cell dissociation, separation into fractions by centrifugation on Percoll® density gradients, and detection of (+)-discodermolide presence by thin layer chromatography. The fractions recovered showed cells of different morphological characteristics, including cyanobacteria, filamentous bacteria, choanocytes, archaeocytes, among others. It was possible to identify an irregular but consistent pattern of (+)-dicordemolide production in the fractions that contained one or more kind of sponge granular cells, indicating that metabolite production seems to be related to the sponge and not with the associated microorganisms.
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