Antifouling paints based on marine natural products from Colombian Caribbean

Santos-Acevedo, Marisol; Puentes, Carlos; Carreño, Katerine; Gomez‐León, Javier; Stupak, Mirta Elena; Garcia, Marie-Carmen; Pérez, María Emilia; Blustein, Guillermo

doi:10.1016/j.ibiod.2013.05.002

Cited by 47 publications

(24 citation statements)

References 63 publications

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“…Many marine benthic organisms (e.g., sponges, mussels, starfishes, sea urchins, algae) are known to harbor anti-fouling metabolites that protect them from deleterious fouling organisms (e.g., [33,[64][65][66][67]). Sea cucumbers do not have visible defensive mechanisms, however their surfaces are free of fouling organisms [40]. Several molecules with various biological activities (e.g., anti-bacterial, anti-fungal, ichthyotoxic) are reported from sea cucumbers, including their anti-fouling properties [38,68].…”

Section: Discussionmentioning

confidence: 99%

“…Saponins have often been described from holothurians including their various biological activities [74]. For example, studies on Holothuria glaberrima [40], H. atra and Holothuria nobilis [38] showed that saponins were responsible for the observed anti-fouling activities. Also, Selvin and Lipton (2004), and Ozupeck and Cavas (2017) found that the saponin-enriched fraction of different sea cucumbers (i.e., Holothuria scabra, Holothuria polii and Holothuria tubulosa) had pronounced anti-fouling properties [41,75].…”

Section: Discussionmentioning

confidence: 99%

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Anti-Fouling Effects of Saponin-Containing Crude Extracts from Tropical Indo-Pacific Sea Cucumbers

et al. 2020

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Sea cucumbers are bottom dwelling invertebrates, which are mostly found on subtropical and tropical sea grass beds, sandy reef flats, or reef slopes. Although constantly exposed to fouling communities in these habitats, many species are surprisingly free of invertebrate epibionts and microfouling algae such as diatoms. In our study, we investigated the anti-fouling (AF) activities of different crude extracts of tropical Indo-Pacific sea cucumber species against the fouling diatom Cylindrotheca closterium. Nine sea cucumber species from three genera (i.e., Holothuria, Bohadschia, Actinopyga) were selected and extracted to assess their AF activities. To verify whether the sea cucumber characteristic triterpene glycosides were responsible for the observed potent AF activities, we tested purified fractions enriched in saponins isolated from Bohadschia argus, representing one of the most active anti-fouling extracts. Saponins were quantified by vanillin-sulfuric acid colorimetric assays and identified by LC-MS and LC-MS/MS analyses. We were able to demonstrate that AF activities in sea cucumber extracts were species-specific, and growth inhibition as well as attachment of the diatom to surfaces is dependent on the saponin concentration (i.e., Actinopyga contained the highest quantities), as well as on the molecular composition and structure of the present saponins (i.e., Bivittoside D derivative was the most bioactive compound). In conclusion, the here performed AF assay represents a promising and fast method for selecting the most promising bioactive organism as well as for identifying novel compounds with potent AF activities for the discovery of potentially novel pharmacologically active natural products.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Anti-Fouling Effects of Saponin-Containing Crude Extracts from Tropical Indo-Pacific Sea Cucumbers

et al. 2020

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“…Natural products from marine organisms are among the most promising antifouling compounds [23,24]. Marine invertebrates are potential sources of bioactive natural products which are used against predators and external threats like biofouling species [25,26]. Sea cucumbers are marine invertebrates belonging to the phylum Echinodermata, class Holothuroidea [27].…”

Section: Introductionmentioning

confidence: 99%

Antifouling and antibacterial activities of bioactive extracts from different organs of the sea cucumber Holothuria leucospilota

et al. 2020

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In this study, antifouling and antibacterial properties of polar, semi polar and non-polar bioactive compounds derived from the sea cucumber Holothuria leucospilota were investigated. A series comprising n-hexane, ethyl acetate and methanol extracts from four different organs of sea cucumber (body wall, gonad, digestive tract and respiratory tree) were investigated for their antibacterial and antifouling activity against two species of microalgae, larvae of barnacle Amphibalanus amphitrite and a non-target organism: larvae of Artemia salina. Results showed that the highest antibacterial activity was found in the ethyl acetate extract of body wall against Staphylococcus aureus with minimum inhibitory concentration (MIC) of 0.250 mg/mL. The MIC of ethyl acetate extract of body wall ranged between 0.062 and 0.250 mg/mL against two microalgal strains. All extracts showed moderate to low toxicity against larvae of barnacles. The most pronounced anti-barnacle activity was found in the ethyl acetate extract of body wall with median lethal concentration (LC 50) value of 0.049 mg/mL. Among the twelve extracts, the ethyl acetate extracts of body wall showed the maximum antibacterial and antifouling activities. The bioactive compounds of the ethyl acetate extract of the sea cucumber body wall were determined using gas chromatography coupled with mass spectrometry. Fatty acids and terpenes were the major compounds, which may be responsible for antibacterial and antifouling activity of the ethyl acetate extract of body wall of the sea cucumber H. leucospilota.

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“…Biological antifouling methods are based either on the secretion of enzymes or metabolites (Cao et al, 2011), and there are many substances with antifouling properties isolated from marine microorganisms, invertebrates or plants (Acevedo et al, 2013;Qian et al, 2010). Furthermore, new physical methods are under development that aim to modify the surface properties (zeta potential, topography, and wettability) and that way alter the biofouling processes (Cao et al, 2011 and references therein).…”

Section: Alternative Antifouling Technologies E Ongoing Research and mentioning

confidence: 99%

Ecotoxicological risk assessment of antifouling emissions in a cruise ship port

Carić

Klobučar

Štambuk

2016

Journal of Cleaner Production

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Antifouling paints based on marine natural products from Colombian Caribbean

Cited by 47 publications

References 63 publications

Anti-Fouling Effects of Saponin-Containing Crude Extracts from Tropical Indo-Pacific Sea Cucumbers

Anti-Fouling Effects of Saponin-Containing Crude Extracts from Tropical Indo-Pacific Sea Cucumbers

Antifouling and antibacterial activities of bioactive extracts from different organs of the sea cucumber Holothuria leucospilota

Ecotoxicological risk assessment of antifouling emissions in a cruise ship port

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