Introduction: It is well known that Parkinson's disease is related to a deficit of dopamine (DA) in the region of the brain called the corpus striatum. The aim of this work is to demonstrate the possibility of in vitro closedloop control of the DA concentration levels. Methods: By applying the electrochemical technique of fast scan cyclic voltammetry (FSCV), the measured values were compared with previously selected ones, and the system made decisions to control infusion pumps by dynamically adjusting the DA concentration in a continuous flow injection cell. Low-cost hardware was used for the acquisition and control signals (Arduino board), whereas for processing the collected data, graphical programming software (LabView) was used. Results: The resolution of the system was approximately 0.4 µmol/L, with a time correction of the concentration adjustable between 1 and 90 seconds. The system allowed control of the DA concentration between 1 and 10 µmol/L with an error of approximately +/-0.8 µmol/L. Conclusion: Although designed to control the DA concentration, the system could be used to control, within the range of the developed FSCV, the concentration of other substances or to turn on brain stimulators. These results encourage the possibility of using the system in clinical studies (in vivo).
RESUMO: Em diálogo com autores de diferentes áreas de conhecimento, argumentamos a necessidade de uma ode aos saberes indígenas. A instauração de uma monocultura da mente, com viés ideológico universalista, vem exterminando a possibilidade de a humanidade se beneficiar com a troca e o compartilhamento de saberes e experiências acumuladas por diferentes povos do Planeta. A hegemonia da lógica de mercado sobrepõe-se a valores imensuráveis, como cooperação, solidariedade, gratidão coletiva e sentimento de parentesco com todas as coisas do mundo. Tais valores estão presentes nas sabedorias milenares que constituem a matriz de uma “ciência primeira”. Também mantêm códigos de conhecimentos e modos de viver que podem vir a se tornar uma referência para resolver problemas enfrentados pelas sociedades modernas. Diante desse cenário, uma atitude ética a ser assumida por uma ciência aberta é a do diálogo com essas cosmologias da tradição. Uma necessária democracia cognitiva, base para a democracia política e justiça social, pode ser alcançada com uma ecologia de ideias.
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