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In recent literature, many researchers have highlighted that the feeling of loneliness can be considered a sign of relevant distress with short- and long-term consequences on the health of people who needs to be appropriately monitored and treated. In this view, the Interpersonal Acceptance–Rejection Loneliness Scale (IPARLS) has been developed to evaluate the subjective feelings and distress related to interpersonal loneliness and to overcome the limits of the previous scales; however, its psychometric characteristics have not yet been fully investigated. Starting from these considerations, two studies have been conducted. The first study, involving 688 adults (19–69 years; 51% females), assessed dimensionality, reliability, and validity of and tested the measurement invariance (MI) of the Italian version of the IPARLS. The second study, involving 205 adults (20–69 years; 51% females), investigated the relationship between loneliness and psychological adjustment. Results confirmed the unidimensionality of the scale and showed that it is reliable, valid, and fully invariant as a function of age and gender. Moreover, data showed a strong association between perceived loneliness and psychological adjustment. The IPARLS is confirmed to be a valid and reliable measure to investigate loneliness in the life cycle from clinical and research perspectives.

Grounded in interpersonal acceptance–rejection theory, this study examined the relation between recollections of parental rejection during childhood and fear of intimacy (FOI) in adulthood, as mediated by adults’ psychological maladjustment. In Study 1, the Fear of Intimacy Scale (FIS) was adapted for use in Italy. Its psychometric properties were investigated in a sample of 635 adults (51% women; 18–35 years). Confirmatory factor analysis, reliability analysis, and measurement invariance analysis showed that the Italian version of the FIS is a valid, reliable, and gender invariant scale. In Study 2, the relations among adults’ recollections of maternal and paternal rejection in childhood, current psychological maladjustment, and self-reported general FOI were investigated in a sample of 360 Italian adults (51% women; 18–35 years). Path analysis showed that the association between recollections of parental rejection during childhood and FOI in adulthood is fully mediated by psychological maladjustment, particularly emotional unresponsiveness, negative self-esteem, and dependency. This model was not moderated by gender. These results provide useful indications for the design of interventions aimed at reducing FOI.

Parental rejection has been consistently empirically implicated in a wide array of developmental, behavioural and psychological problems worldwide. However, the interaction effect between parental rejection in childhood and the oxytocin receptor genotype on psychological adjustment has yet to be investigated. The present study aimed to investigate gene–environment interaction effects between parental rejection (maternal and paternal) and oxytocin receptor (OXTR) gene polymorphisms (rs53576 and rs2254298) on depressive symptoms in adults in different cultural contexts. Adults from Italy and Japan (N = 133, age = 18–27 years, females = 68) were preliminarily genotyped and then completed the Parental Acceptance-Rejection Questionnaire for mothers and fathers and the Beck Depression Inventory. Hierarchical multiple regression analysis showed that paternal rejection was related to self-reported depression and that the effect of parental rejection was moderated by OXTR gene polymorphisms and nationality. Among Italians, OXTR rs2254298 A-carriers showed resilience to negative early parental care, whereas among Japanese, OXTR rs53576 non-A-carriers showed resistance to negative early paternal care. These findings align with expected relations between perceived acceptance–rejection and an individual’s psychological adjustment, as proposed by interpersonal acceptance–rejection theory, and indicate the need for future studies adopting a multicultural and multilevel approach to better understand how the effects of parental rejection extend into adulthood.

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