The use of nursing assistance systematization for diabetic patients in health unities of coronel Fabriciano, Minas Gerais RESUMOO processo de enfermagem é um método científico com a finalidade de identificar e auxiliar na solução dos problemas de saúde dos clientes. O objetivo deste estudo foi avaliar a utilização do processo de enfermagem no atendimento de pacientes diabéticos em duas Unidades Básicas de Saúde da Família e um Hospital Geral de Coronel Fabriciano, Minas Gerais, durante o ano de 2005. O estudo retrospectivo e documental foi realizado por meio da análise dos registros contidos nos prontuários de 45 pacientes, 15 internados e 30 em seguimento nas Unidades Básicas de Saúde. Os dados obtidos foram divididos de acordo com as etapas de processo de enfermagem: histórico, diagnóstico, plano de cuidados, implementação e avaliação ou evolução de enfermagem. Os resultados indicam que na amostra estudada, os enfermeiros registravam de maneira incompleta suas ações de saúde e não utilizavam o processo de enfermagem. Vale ressaltar a necessidade de se estimular a aplicação do processo de enfermagem e do registro das ações de controle, prevenção de complicações tratamento e evolução do Diabetes pela equipe de enfermagem, visando a melhoria da qualidade do serviço prestado.
Cytoplasmic microtubules are important in many cellular homeostatic processes in the cell. They regulate cell shape and movement as well as serving as a network by which vesicles and membrane-bound organelles can travel. Lately, there have been many studies demonstrating that microtubules are involved in regulation of intracellular signaling and, therefore, affect vascular reactivity. In this study, we tested the hypothesis that microtubule disruption attenuates agonist-induced endothelium-dependent vasodilation. Isolated mesenteric arterial bed from normotensive rats was preconstricted with phenylephrine, and dose-response curves for histamine, acetylcholine (ACh), sodium nitroprusside (SNP), and pinacidil were performed before and after incubation with nocodazole or colchicine. Treatment of the vascular beds with nocodazole or colchicine significantly attenuated histamine relaxation but did not change the ACh-, SNP-, or pinacidil-induced vasorelaxation. Nocodazole did not cause an additional attenuation of the histamine-mediated dilation in mesenteric vessels in the presence of N -nitro-L-arginine methyl ester, high extracellular K ϩ , or K ϩ channel blockers. These data suggest that disruption of microtubules affects an essential endothelial component of histamine-mediated vasodilation in the mesenteric arterial bed. The mechanism(s) involved in this effect might be related to an impairment of endothelial NO synthesis, which might not be as important for the ACh as for the histamine vasodilator response in rat mesenteric vessels. These results demonstrate the importance of the microtubular system for endothelium-dependent NO-mediated smooth muscle relaxation.nocodazole; nitric oxide; mesenteric arterial bed EUKARYOTIC CELLS CONTAIN a complex set of protein fibers found in the cytoplasm-the cytoskeleton. The cytoskeleton contains three major classes of fibers: actin microfilaments, microtubules (MTs), and intermediate filaments. MTs, a major component of the cytoskeleton, are cylindrical structures composed of two types of protein, ␣-and -tubulin. In general, the biological functions of MTs are partially based on the ability of tubulin to polymerize and depolymerize. In living cells the MTs are in a dynamic process between tubulin dimers and tubulin polymerized into MTs (8).MTs play a role in a variety of cellular functions, including mitosis, trafficking of proteins, shape, and signaling processes (16). In recent years, the role of the MT network in transduction processes in the cell has been the object of several studies. It has been shown that MTs are associated with a variety of proteins involved in cell signaling, including adenylate cyclase (42), phospholipase C (41), and small G proteins (6).The use of various pharmacological agents that affect the polymerization state of the MT network has yielded many novel relationships between MTs and those cell signaling pathways. Nocodazole and colchicine, two destabilizing agents, bind to the colchicine binding site of tubulin, shifting the dynamic state of MTs ...
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