(R)‐Propylene carbonate is an important intermediate in the synthesis of tenofovir pro‐drugs such as tenofovir alafenamide fumarate (TAF) and tenofovir diisoproyl fumarate (TDF). Independent of the pro‐drug type, tenofovir presents a chiral secondary hydroxy derivative, which can be obtained directly from (R)‐propylene carbonate. Herein, we report our chemo‐enzymatic continuous‐flow strategy towards (R)‐propylene carbonate starting from a very cheap and renewable raw material, glycerol. We were able to synthesize (R)‐propylene carbonate in seven continuous‐flow steps, starting from glycerol, in good‐to‐excellent yields (66–93 %) and excellent selectivity (E > 200).
A utilização de irradiação de micro-ondas tem se difundido entre os químicos orgânicos sintéticos. No entanto, o cuidado quanto à reprodutibilidade e ao correto uso dos equipamentos pode vir a ser no futuro um entrave à utilização dos mesmos. Sendo assim, neste trabalho viemos esclarecer alguns pontos e demonstrar como alguns cuidados podem fazer diferença durante o processo de irradiação de micro-ondas.Palavras-chave: irradiação de micro-ondas, efeito térmico, efeito de micro-ondas, temperatura.The use of microwave irradiation has been widespread among synthetic organic chemists. However, proper care about the reproducibility and the correct use of equipment may become an obstacle to the future use of this technology. Thus, in this work we would like to clarify some points and show how the adequate use of temperature measurement can make a difference during the microwave irradiation.
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