In two simultaneously‐taken needle biopsies of the liver from 70 consecutive patients, a number of changes were evaluated semiquantitatively and compared in n × m tables. The lesions examined were steatosis, Mallory's hyalin, alcoholic hepatitis, cirrhosis and cholestasis; furthermore the size, amount of inflammatory cells, connective tissue and bile‐duct proliferation of the portal tracts and finally focal necroses and acidophilic bodies in the lobules were recorded. Cirrhosis, cholestasis and steatosis showed a high correlation, while the agreement between the two interdependent biopsies, especially concerning acidophilic bodies and bile‐duct proliferation, was low. Possible reasons for the variation in the agreement of the lesions are discussed.
In 70 consecutive patients the histopathological diagnosis of needle liver biopsy specimens and the clinical diagnosis were compared. The patients were divided into the following groups: alcoholic liver disease, hepatitis, malignancy, cholestasis, and miscellaneous. Nearly half of the cases were alcohol-induced; all of these showed changes in the specimens consistent with an elevated alcohol consumption, but their histopathological 'severity' did not correlate with the amount of alcohol consumption. In the hepatitis group three cases of acute viral hepatitis gave identical clinical and histopathological diagnoses. The malignancy group showed that in five of eight cases the needle biopsy specimen confirmed the clinical suspicion of malignant tumour in the liver. The histopathological diagnoses of the miscellaneous group were not able to add further information to the clinical findings because of unspecific lesions in the specimens. Two specimens were taken from each patient, and the 'reproducibility' of the histopathological diagnoses of the interdependent specimens showed a high degree of agreement: 71% of the biopsy pairs had identical diagnoses of the two specimens from the same patients, and 12% of the biopsy pairs had only small differences between the two diagnoses.
Renal xenotransplantation between cat (donor) and rabbit (recipient) leads to hyperacute rejection and destruction of the graft in a few hours. Infusion of donor blood to the recipient prolongs the graft survival considerably.
Survival of renal xenografts from rabbit to cat has been prolonged by several hours by injection of antibodies against cat serum into the recipient. In control experiments the transplanted rabbit kidney was rejected by the cat in a few minutes.
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