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The application of the mass fragmentographic technique has aUowed accurate identification of a tricyclic antidepressant drug, nortriptyline, and some of its metabolites in biological fluids from patients treated with therapeutic doses and from one patient intoxicated with the same drug. Mass fragmentography in combination with the scanning of mass spectra of compoundy eluted from the gas chromatography column made it possible to identify nortriptyline and the metabolites, desmethylnortriptyline, lO-hydroxynortriptyline, and, tentatively, lO-hydroxydesmethylnortriptyline.