Mass fragmentography

Hammar, Carl-Gustaf; Holmstedt, Bo; Ryhage, Ragnar

doi:10.1016/0003-2697(68)90131-0

Cited by 310 publications

(46 citation statements)

References 19 publications

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“…The detection of compounds labelled with stable isotopes is principally carried out by mass spectrometry, which can detect the associated increase in mass. 1,2 Additionally, to distinguish the stable isotope labelled compound from other compounds present in the complex mixtures obtained from biological materials, an advantageous technique has been developed ; namely the cluster ion method3-' using an equimolar mixture of stable isotope labelled and unlabelled compounds. In this method, to avoid the influence of isotope peaks by the natural abundance of 13C, labelled compounds are at least two or more mass units larger in molecular weight than the unlabelled compounds.…”

Section: Introductionmentioning

confidence: 99%

A new technique for the detection of metabolites labelled by the isotope13C using mass fragmentography

Sano

Yotsui

Abe

et al. 1976

Biol. Mass Spectrom.

128

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Section: Introductionmentioning

confidence: 99%

A new technique for the detection of metabolites labelled by the isotope13C using mass fragmentography

Sano

Yotsui

Abe

et al. 1976

Biol. Mass Spectrom.

128

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“…Mass fragmentography (Hammar, Holmstedt & Ryhage, 1968) has found an increasing use in the determination of small amounts of drugs and endogenous com-pounds (cf. Borgi, PalmCr & others, 1972).…”

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confidence: 99%

Quantitation of Δ1-tetrahydrocannabinol in plasma from cannabis smokers

Agurell¹,

Gustafsson²,

Holmstedt

et al. 1973

Journal of Pharmacy and Pharmacology

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A method to identify and accurately measure non-labelled Al-tetrahydrocannabinol (A1-THC) in blood of cannabis smokers has been developed. It consists of the following steps : To a 5 ml plasma sample is added deuterated A1-THC (A1-THC-d,) as internal standard. After extraction with light petroleum and evaporation, the A1-THC containing fraction is separated by chromatography on Sephadex LH-20 (1 x 40 cm) using light petroleum-chloroform-ethanol (10: 10: 1) as eluant. A fraction containing A1-THC is collected and subjected to mass fragmentography (LKB 9000; 3 % OV-l7/GasChrom Q; 230"). The mass spectrometer was adjusted to record the intensities of mle 299 and 314 of A1-THC and mle 301 and 316 of Al-THC-d,. The standard curve was made by plotting peak height m/e 299/m/e 301. Peak levels of 19-26 ng ml-l were reached within 10 min after smoking a cigarette containing 10 mg Al-THC.

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“…So far, during our work on the biosynthesis of cactus alkaloids all precursors have been found to be phenolic amines [3,4] . Thus, a number of cacti were investigated mainly for the presence of phenolic amines.…”

Section: Resultsmentioning

confidence: 99%

“…N-Methyl-3-methoxy4-hydroxyphenethylamine was prepared by methylation of 3-methoxy4-benzyloxyphenethylamine [7] and subsequent debenzylation [7] . The principles of mass fragmentography and the technical details have been described [4,6] and with later modifications by Hammar and Hessling [5]. Further informations are given in legends to figs.…”

Section: Introductionmentioning

confidence: 99%