The boreal and boreo-nemoral forests in Europe, which occur in northern and northeastern Europe, are dominated by 2 coniferous species, Norway spruce Picea abies (L.) Karst. being economically the most important one. Forestry is of major economic importance in this region. Forestry planning and climate change scenarios are based on similar (long-term) timescales, i.e. between 70 and 120 yr. Within the EU project 'Modelling the Impact of Climate Extremes' (MICE), we have used 'present day ' runs (1961-1990) and future scenarios (2070-2100, emission scenarios A2 and B2 from the Special Report on Emissions Scenarios [SRES]) of the HadRM3 regional climate model to study and model direct and indirect effects of changing climate on Norway spruce in Sweden and northern Europe. According to our results, extreme climate events like spring temperature backlashes and summer drought will increase in frequency and duration. In combination with a raised mean temperature, climate extremes will negatively precondition trees (i.e. increase their susceptibility) to secondary damage through pests and pathogens. Decreased forest vitality also makes stands more susceptible to windthrow. Storm damage is discussed based on a 100 yr storm damage record for Sweden. Marginally increased frequencies and windspeeds of storms may cause disproportionate increases in windthrow. Increased economic hazards can be expected from a combination of the increased volumes of wind-thrown timber, and a greater likelihood of additional generations of spruce bark beetle Ips typographus (further encouraged by the increase in fallen timber), as a result of a changing climate with warmer summers.

This study indicated that simple in vitro methods of in vivo precipitation of orally administered bases overpredict the intestinal crystalline precipitation in vivo in humans. Hydrodynamic conditions were identified as one important factor that needs to be better addressed in future in vivo predictive methods.

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Altered lipid handling and hormone secretion in the gut were demonstrated during 1-week treatment with the DGAT1 inhibitor AZD7687. However, the apparent lack of therapeutic window owing to GI side effects of AZD7687, particularly diarrhoea, makes the utility of DGAT1 inhibition as a novel treatment for diabetes and obesity questionable.

We describe the process of building a climate service centred on regional climate model results from the Rossby Centre regional climate model RCA4. The climate service has as its central facility a web service provided by the Swedish Meteorological and Hydrological Institute where users can get an idea of various aspects of climate change from a suite of maps, diagrams, explaining texts and user guides. Here we present the contents of the web service and how this has been designed and developed in collaboration with users of the service in a dialogue reaching over more than a decade. We also present the ensemble of climate projections with RCA4 that provides the fundamental climate information presented at the web service. In this context, RCA4 has been used to downscale nine different coupled atmosphere-ocean general circulation models (AOGCMs) from the 5th Coupled Model Intercomparison Project (CMIP5) to 0.44° (c. 50 km) horizontal resolution over Europe. Further, we investigate how this ensemble relates to the CMIP5 ensemble.We find that the iterative approach involving the users of the climate service has been successful as the service is widely used and is an important source of information for work on climate adaptation in Sweden. The RCA4 ensemble samples a large degree of the spread in the CMIP5 ensemble implying that it can be used to illustrate uncertainties and robustness in future climate change in Sweden. The results also show that RCA4 changes results compared to the underlying AOGCMs, sometimes in a systematic way.