Resumo: Introdução: O terapeuta ocupacional é um dos profissionais que pode compor a equipe multiprofissional que desenvolve o trabalho de apoio matricial no Sistema Único de Saúde (SUS). Objetivo: Este estudo teve como objetivo caracterizar a prática de apoio matricial em saúde realizado pelo terapeuta ocupacional no SUS a partir de uma pesquisa bibliográfica realizada em periódicos brasileiros de terapia ocupacional. Método: Foram selecionados cinco artigos que compuseram o estudo. Para análise dos materiais, foram estabelecidas a priori as seguintes categorias: os tipos de serviço de saúde onde é realizado o apoio matricial pelo profissional; os profissionais envolvidos com o apoio matricial; a população e as situações de saúde ou condições sociais trabalhadas; os objetivos do apoio matricial; as características das intervenções e os desafios enfrentados pelo terapeuta ocupacional. A análise dos dados foi realizada a partir da descrição dos dados. Resultados: O apoio matricial foi apresentado como atribuição multiprofissional na atenção primária à saúde (APS). O público-alvo foram crianças, adultos, idosos, familiares, cuidadores e profissionais. As demandas para o apoio matricial foram assistenciais, sociais e em educação permanente em saúde. As ações tiveram como objetivos instrumentalizar os profissionais com ferramentas para o cuidado integral na APS e implementar ações, em projetos terapêuticos e institucionais compartilhados, voltadas ao desempenho ocupacional, ao pertencimento e à participação da pessoa em sua comunidade, bem como ao controle social no SUS. Conclusão: Apresentou-se como desafio a fundamentação para a prática do terapeuta ocupacional no apoio matricial em saúde. Palavras-chave: Terapia Ocupacional, Apoio Matricial, Sistema Único de Saúde. The matrix support health by occupational therapists in Brazilian Unified Health SystemAbstract: Introduction: The occupational therapist is one of the professionals that composes multidisciplinary team that develops the matrix support in the Unified Health System (UHS). Objective: This study aimed to describe the matrix support practice undertaken by occupational therapists in UHS based on a bibliographical research performed in Brazilian occupational therapy journals. Method: Five articles composed this study. The analysis was previously established with the following categories: types of health service where the matrix support is performed; professional involved with the matrix support; population and health or social conditions; matrix support objectives; intervention features and occupational therapists' challenges. Data analysis was performed from the description of the data. Results: Matrix support was presented as a multiprofessional assignment in Primary Health Care (PHC). The target audience were children, adults, the elderly, familily members, caregivers and health professionals. Health assistance, social assistance and continuous health education were the matrix support demands. The objectives were to equip the professionals with health tec...
For upland rice, it is desired, among many objectives, to obtain highly productive and early genotypes, consequently reducing the risk of establishing a crop regarding climatic adversities. Therefore, this study aimed to verify the correlation between the agronomic traits days to flowering and grain yield of 14 upland rice lines. The experiment was conducted in seven environments, in the 2013/14, 2014/15 and 2015/16 crop years, in a randomized complete block design with three replications. Both the genotypic and phenotypic correlation were significant and positive, whereas the genotype correlation was superior to the phenotype. However, it was noted a low magnitude of the correlation values. It was concluded that a favorable and simultaneous selection is possible for high grain yield and plants with early blossoming cycle in upland rice.
Background: The treatment of chronic myeloid leukemia (CML) employs drugs known as tyrosine kinase inhibitors (TKIs). Comparative analyses of the effects of different TKIs has shown that these substances can reduce the immunogenicity of leukemic cells, and prejudice anti-tumoral immunity. Once the TKIs differ in terms of their direct influence on cells of the immunological system, the objective of this work was therefore to analyze alterations in the immunological systems of CML patients using different TKI drugs. Methodology/Principal findings:A review of the literature revealed that imatinib is considered to be the new paradigm for treatment of CML; however, use of this drug can result in inhibition of activation of immune system cells and development of resistance. Second and third generation TKIs can be used in the treatment of patients resistant to imatinib, but can have immunosuppressor effects. Nilotinib is more effective than imatinib in recently-diagnosed patients, however at high doses can induce myelosuppression and diminish cytokine production. Dasatinib was found to induce a rapid full cytogenetic response, with heightened in vivo immune-stimulation, in contrast to an immunosuppression observed in vitro. The mutated T315I phenotype of CML only shows a response to treatment with inhibitors that do not compete with ATP, involving aurora kinases that control mitosis, progression of the cellular cycle, and apoptosis induction. MK0457, which is able to act in the presence of the mutation, presents important bone marrow toxicity, while in small doses danusertib has shown anti-proliferative and pro-apoptotic activity against a wide spectrum of BCR-ABL-positive cells.Conclusions/Significance: Selection of the most suitable tyrosine kinase inhibitor in patients showing positive to the BCR-ABL mutation requires previous analysis of the phenotype and the influence of the TKI on the immunological system.
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