New materials are required for bone healing in regenerative medicine able to temporarily substitute damaged bone and to be subsequently resorbed and replaced by endogenous tissues. Taking inspiration from basic composition of the mammalian bones, composed of collagen, apatite and a number of substitution ions, among them magnesium (Mg 2+ ), in this work, novel composite scaffolds composed of collagen(10%)-hydroxyapatite (HAp)(90%) and collagen(10%)-HAp(80%)-Mg(10%) were developed. The lyophilization was used for composites preparation. An insight into the nanostructural nature of the developed scaffolds was performed by Scanning Electron Microscopy coupled with Energy Dispersive X-Ray and Transmission Electron Microscopy coupled with Energy Dispersive X-Ray. The HAp nanocrystallite clusters and Mg nanoparticles were homogeneously distributed within the scaffolds and adherent to the collagen fibrils. The samples were tested for degradation in Simulated Body Fluid (SBF) solution by soaking for up to 28 days. The release of Mg from collagen(10%)-HAp(80%)-Mg(10%) composite during the period of up to 21 days was attested, this composite being characterized by a decreased degradation rate with respect to the composite without Mg. The developed composite materials are promising for applications as bone substitute materials favouring bone healing and regeneration.
A case study of a failed humeral shaft locking compression plate is presented, starting with a clinical case where failure occurred and an implant replacement was required. This study uses finite element method (FEM) in order to determine the failure modes for the clinical case. Four loading scenarios that simulate daily life activities were considered for determining the stress distribution in a humeral shaft locking compression plate (LCP). Referring to the simulation results, the failure analysis was performed on the explant. Using fracture surface investigation methods, stereomicroscopy and scanning electron microscopy (SEM), a mixed mode failure was determined. An initial fatigue failure occurred followed by a sudden failure of the plate implant as a consequence of patient’s fall. The fracture morphology was mostly masked by galling; the fractured components were in a sliding contact. Using information from simulations, the loading was inferred and correlated with fracture site and surface features.
Magnesium alloys as bioresorbable materials with good biocompatibility have raised a growing interest in the past years in temporary implant manufacturing, as they offer a steady resorption rate and optimal healing in the body. Magnesium exhibits tensile strength properties similar to those of natural bone, which determines its application in load-bearing mechanical medical devices. In this paper, we investigated the biodegradation rate of Mg-Zn-Mn biodegradable alloys (ZMX410 and ZM21) before and after coating them with hydroxyapatite (HAP) via the electrophoretic deposition method. The experimental samples were subjected to corrosion tests to observe the effect of HAP deposition on corrosion resistance and, implicitly, the rate of biodegradation of these in simulated environments. X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS) provided detailed information on the quality, structure, and morphology of the HAP coating. The obtained results demonstrate that coating of Mg-Zn-Mn alloys by HAP led to the improvement of corrosion resistance in simulated environments, and that the HAP coating could be used in order to control the biodegradation rate.
The objective of an articular cartilage repair treatment is to repair the affected surface of an articular joint's hyaline cartilage. Currently, both biological and tissue engineering research is concerned with discovering the clues needed to stimulate cells to regenerate tissues and organs totally or partially. The latest findings on nanotechnology advances along with the processability of synthetic biomaterials have succeeded in creating a new range of materials to develop into the desired biological responses to the cellular level. 3D printing has a great ability to establish functional tissues or organs to cure or replace abnormal and necrotic tissue, providing a promising solution for serious tissue/organ failure. The 4D print process has the potential to continually revolutionize the current tissue and organ manufacturing platforms. A new active research area is the development of intelligent materials with high biocompatibility to suit 4D printing technology. As various researchers and tissue engineers have demonstrated, the role of growth factors in tissue engineering for repairing osteochondral and cartilage defects is a very important one. Following animal testing, cell-assisted and growth-factor scaffolds produced much better results, while growth-free scaffolds showed a much lower rate of healing.
The developement and regeneration of healthy bone tissue is a complex process that includes the interaction of different cell types and requires a set of coordinated processes. The loss of bone tissue may occur due to various reasons: surgical removal, bone trauma (i.e., fractures) or systemic bone loss (i.e., osteoporosis). When the natural bone tissue is destroyed, the regeneration capacity of the bone is not always satisfactory. The result consists therefore in many functional and structural aberrations. In order to improve and accelerate the healing process, bone substitutes have been developed. Hydroxyapatite has been widely used in bone applications due to its excellent biocompatibility, osteoconductivity and bioactivity [1,2]. The objective of this research is to obtain a new composite biomaterial that can be used as bone substitute. In this study, bovine hydroxyapatite obtained from freshly calcined bovine femur was used. The objective of this research is to obtain a new composite biomaterial that can be used as bone substitute. The experimental composite samples were obtained using bovine hydroxyapatite as matrix and tricalcium phosphate, respectively, magnesium oxide as reinforcement materials. The synthesis process of these new biomaterial composites, the effect of chemical composition, surface structure, chemical and phase composition as well as mechanical features have been investigated.
Bone reconstruction is a complex process which involves an osteoconductive matrix, osteoinductive signaling, osteogenic cells, vascularization and mechanical stability. Lately, to improve the healing of the bone defects and to accelerate the bone fusion and bone augmentation, bioceramic composite materials have been used as bone substitutes in the field of orthopedics and dentistry, as well as in cosmetic surgery. Of all types of bioceramics, the most used is hydroxyapatite, because of its similar properties to those of the human bone and better mechanical properties compared to b-tricalcium phosphate [1]. Currently, the most used raw materials sources for obtaining the hydroxyapatite are: bovine bone, seashells, corals, oyster shell, eggshells and human teeth. There are two common ways to obtain hydroxyapatite: synthetically and naturally. Generally, for the improvement of the mechanical properties and the structural one, hydroxyapatite is subjected to the sintering process. Considering the disadvantages of hydroxyapatite such as poor biodegradation rate, b-TCP has been developed, which has some disadvantages too, such as brittleness. For this reason, the aim of this study is to look into the effect of adding magnesium oxide on the sintering behavior, the structure and the mechanical properties of the hydroxyapatite-tricalcium phosphate composites.
Hallux valgus represents an acquired foot deformity defined by medial deviation of the first metatarsal bone combined with lateral shift of the hallux and medial metatarsophalageal joint eminence enlargement. The functional impairment and metatarsalgia generated stem from the biomechanical imbalance which does not allow for normal transfer of weight trough the first ray during walking. The results generated with our experience with the 1.1mm Mini TightRope® Disposable Kitin the treatment of hallux valgus are analyzed in this paper. A total number of 24 feet (12 bilateral cases) with hallux valgus, surgically treated in our department were followed for a period of minimum twelve months and evaluated. The results showed an improvement of the mean preoperative IMA 14.6°to 7.9° postoperatively and 9.2° at six months after surgery. The preoperative measured HVA was reduced from 28.4to 14.2° at once and 16.1° after six months. The AOFAS hallux metatarsophalangeal-interphalangeal score resulted improvement reflects the functional benefits. These results confirm the good correction potential of the technique and support it as avalid treatment option for mild to moderate severity hallux valgus.
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