Many metal−organic frameworks have been designed and synthesized for biosensors because of high surface area and porosity, suitable size, and good biocompatibility. Despite recent advances, however, most of them are only used as a nanocarrier. In this work, a new artificial nanozyme was constructed on a metalloporphyrinic metal−organic framework (PMOF(Fe)), which was formed by Fe porphyrin and Zr 4+ ions. Then, ultrasmall Pt nanoparticles (Pt NPs) were loaded on the surface of PMOF(Fe) to form Pt@ PMOF(Fe). Because of the high surface area and exposed Fe activity center, PMOF(Fe) works as a nanocarrier to hinder the Pt NP aggregation and exhibits high peroxidase-mimicking activity. Hence, Pt NPs decorated on the surface of PMOF(Fe) possessed high stability and exhibited high activity. Due to the synergistic effect between PMOF(Fe) and Pt NPs, Pt@PMOF(Fe) exhibits superior catalase-and peroxidase-like activities. Moreover, Pt@PMOF(Fe) possesses high electrocatalytic activity toward the reduction of H 2 O 2 and the oxygen reduction reaction (ORR). This strategy may serve as a strong foundation to design MOF-based artificial nanozymes and develop an ideal platform for MOFs and nanozymes toward artificial enzymatic catalytic systems, fuel cells and new analytical applications.
An enzyme-immobilized metal-organic framework (MOF) nanosheet system was developed as a tandem catalyst, which converted glucose into gluconic acid and H2O2, and sequentially the latter could be used to catalyze the oxidation of l-arginine to generate nitric oxide in the presence of porphyrinic MOFs as artificial enzymes under physiological pH, showing great potential in cancer depleting glucose for starving-like/gas therapy.
A metal–organic framework nanosheet with flower-like structure was designed as a probe for H2S detection and in situ singlet-oxygen production under physiological pH.
Metal-Organic Framework (MOF) with large surface area, exposed active site, excellent catalytic performance and high chemical stability has been used as artificial enzymes and designed for nonenzymatic electrochemical sensors. Here,...
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