We identified 42 patients with spirometrically-significant AR, 56 patients with stable AR, and 81 patients with stable no-AR with available BAL samples (one sample per patient). BAL at time of spirometrically-significant AR, compared to other groups, had elevated levels of TCA (ANOVA<0.05), as well as markers of inflammation (IL6, CXCL8, S100A8, IL1b, and S100A12) (ANOVA<0.05 for all). In multivariable models, levels of GCA and TCA were associated with allograft survival independent of AR group (P<0.05 for both). These are preliminary results that are now being reviewed by co-authors from all sites. Additional analyses are ongoing. This is an ancillary study of the CTOT-20 multi-center trial: approval of the abstract by the CTOT publication committee is pending.
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