Within two weeks, all symptoms and signs had subsided, including the arthralgias, fevers, malaise, anorexia, photo¬ phobia, and hepatomegaly. She started to gain weight. Within six weeks the labora¬ tory findings had returned to normal lev¬ els. The hemoglobin level was 14.3 gm/100 ml; hematocrit reading, 44%; leukocyte count, 5,800/cu mm; differential cell count was normal, and erythrocyte sedimenta¬ tion rate was 18 mm/hr. A second study of the serum for antinuclear antibody was negative, and the serum protein electrophoresis was normal. The patient re¬ mained symptom-free and without labora¬ tory evidence of disease during the next six months.Comment-in this case of systemic lupus-like reaction with positive antinuclear factor, the responsible agent appears to have been clofibrate. The absence of any other medication, and the disappearance of all symptoms and laboratory abnormalities follow¬ ing discontinuation of clofibrate, strongly suggest a causative associa¬ tion between the drug and the lupus¬ like syndrome.Clofibrate should be listed among those drugs capable of inducing the "lupus" reaction.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.