Ampicillin-Resistant Shigella

Abstract

Within two weeks, all symptoms and signs had subsided, including the arthralgias, fevers, malaise, anorexia, photo¬ phobia, and hepatomegaly. She started to gain weight. Within six weeks the labora¬ tory findings had returned to normal lev¬ els. The hemoglobin level was 14.3 gm/100 ml; hematocrit reading, 44%; leukocyte count, 5,800/cu mm; differential cell count was normal, and erythrocyte sedimenta¬ tion rate was 18 mm/hr. A second study of the serum for antinuclear antibody was negative, and the serum protein electrophoresis was normal. The patient re¬ mained symptom-free and without labora¬ tory evidence of disease during the next six months.Comment-in this case of systemic lupus-like reaction with positive antinuclear factor, the responsible agent appears to have been clofibrate. The absence of any other medication, and the disappearance of all symptoms and laboratory abnormalities follow¬ ing discontinuation of clofibrate, strongly suggest a causative associa¬ tion between the drug and the lupus¬ like syndrome.Clofibrate should be listed among those drugs capable of inducing the "lupus" reaction.

Antimicrobial Resistance of Shigella Isolated in New York City in 1973

“…The reason for the low resistance to kanamycin and cephalothin is unclear, but suggests that the R factors are those currently prevalent in E. coli (12). Our sample of S. flexneri is small and it would be unwise to overly stress the lower resistance, but is similar to the Dallas study (Haltalin et al) in contrast to a report from Kansas City (17). Data from Vietnam (9) showed that although tetracycline resistance was equivalent in S. flexneri types 1 to 6, ampicillin resistance ranged from 2 to 25%.…”

“…These hospitals cover ghetto areas in three different areas of the city. The other 55 strains came from other municipal hospitals (38) in other parts of the city or from voluntary hospitals (17 17 (53%) were susceptible to all antibiotics. These differences are unexplained at present.…”

Infectious diseases: annual review of significant publications

“…'05 Person-to-person spread of Yersinia enterocolitis affected six hospital employees.106 During 5 years, the incidence of ampicillin-resistant shigellae increased from none to 85YO. 107 Lomotil therapy for shigellosis prolonged the fever and caused other harmful effects.107a…”