To determine the prevalence of congenital melanonevocytic nevi (CMN), of so-called congenital nevus-like nevi (CNLN), nevi spili (NS) and café-au-lait spots (CLS) in childhood, a series of 939 children aged 8–16 years had total skin examination. CMN/CNLN were observed in a frequency of 5.9% NS in 2.1 % and CLS even in 32.7%. Except CLS (which occurred more frequently in boys) all of these lesions were equally represented in both sexes. According to the classification of Kopf and coworkers, 44/55 CMN/CNLN were small and 11/55 medium-sized. CMN/CNLN affected preferentially trunk and upper limbs while head and neck were spared. Such nevi occurred more frequently in dark types of skin complexion and showed a tendency to be more frequent in groups of patients with increased average number of acquired melanonevocytic nevi. Remarkably, CLS were also found in 23/55 (41.7%) children with CMN/CNLN and in 12/20 (60%) children with NS (in a higher frequency than such combinations have to be expected). Compared with the data from other studies both CMN/CNLN and CLS in our patients were observed in highest prevalence in the literature. Since the frequency of CLS in adults is much lower, it cannot be ruled out that some of the CLS disappear in adolescence.

In 939 schoolchildren aged 8–16 years skin complexion was determined by a system of seven categories. Anamnestic data concerning tanning ability and history of sunburns, however, were not considered owing to their obvious unreliability in children. Mean nevus count was 17.97 was significantly higher in boys than in girls and increased with age. There was a clear relation of mean nevus number and skin complexion: in fair skin type nevi are most frequent decreasing in number by increasing of pigment content. Additionally, children with freckles have higher mean nevus count in every category of skin complexion. All literature data critically reviewed as dealing with mean mole count are not comparable in several respects. In different races however such studies may serve as a basis for subsequent investigations concerning the questions of probably increasing number of melanonevocytic nevi.

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In 2 cases with the classical clinical features described in connection with papillomatose papuleuse confluente et réticulée amyloid deposits could be demonstrated by histochemical (alkaline Congo red and thioflavin T reaction) and electron microscopical means. These results allow to discuss the nosological position of this disease.

electron microscopy (4 cases with oligoastheno-teratozoospermia and 3 cases with oligozoospermia). The average age of these 7 patients was 29 years.17 testicular biopsies from patients with disturbed fertility, classified in a previous pa-