Frequency of Congenital Nevi, Nevi spili and Café-au-Lait Spots and Their Relation to Nevus Count and Skin Complexion in 939 Children

Sigg, C; Pelloni, F.; Schnyder, U. W.

doi:10.1159/000248009

Cited by 61 publications

(38 citation statements)

References 11 publications

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“…Our patients showed a higher frequency of both CN/CNLN and AN, with respect to the frequencies reported in the general Caucasian population [9][10][11]. Regardless of their karyotype.…”

Section: Discussionsupporting

confidence: 46%

The dermatological spectrum of Turner syndrome

Borroni

Larizza

Vignati

et al. 1994

Acad Dermatol Venereol

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II •Turner syndrome, characterized by monosomy of X chromosome, has a peculiar phenotype, including short stature, sexual infantilism, cardiovascular, renal, skeletal and skin abnormalities {in particular melanocytic naevi and skin appendage abnormalities). Fifty-four patients affected by Turner syndrome were investigated. The skin and adnexal changes of Turner syndrome patients were analysed and their frequency was correlated with two karyotype groups {45,X and mosaicism group). A wide spectrum of skin findings was observed in Turner syndrome; in particular melanocytic naevi and pterygium eolli were the most frequent findings. Pterygium colli was more frequent in patients with X monosomy than in those with other karyotypes (/'<0.05). The frequency of congenital/congenital-naevus-like naevi (CN/CNLN) and acquired melanocytie naevi (AN) (81.6%) was higher in Turner syndrome subjects, independently of their karyotype, than in the general Caucasian population. However, there was an unexpectedly high frequency of ichthyotic changes, cafe-au-lait spots and halo naevi. Hypertrichosis, nail changes and keloid formation were also seen. No significant correlation was found between these dermatologieal findings and the two karyotype groups considered.Although there are no reports on the occurrence of melanoma in Turner syndrome, given the high prevalence of both small congenital and acquired naevi, these patients should also be considered for melanoma prevention.

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“…Our patients showed a higher frequency of both CN/CNLN and AN, with respect to the frequencies reported in the general Caucasian population [9][10][11]. Regardless of their karyotype.…”

Section: Discussionsupporting

confidence: 46%

The dermatological spectrum of Turner syndrome

Borroni

Larizza

Vignati

et al. 1994

Acad Dermatol Venereol

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“…7 Whereas the prevalence of NS and CNLN was comparable to Kopf and colleagues' data, the prevalence of CLSs was much higher. 5,6 As the classification of pigmented lesions has been expanding to include new entities, we were interested in studying the terminology and prevalence of various pigmented lesions in a cohort by examining total-body digital photographs of patients from the Dermatology Service at Memorial Sloan-Kettering Cancer Center.…”

supporting

confidence: 53%

Classification and Prevalence of Pigmented Lesions in Patients with Total-Body Photographs at High Risk of Developing Melanoma

et al. 2006

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“…SLN occurs in about 1–2% of schoolchildren and adults [9,10,11], mostly as an isolated rather small lesion. In some cases, however, large skin segments may be involved in a checkerboard pattern [12,13,14].…”

Section: Introductionmentioning

confidence: 99%

Two Distinct Types of Speckled Lentiginous Nevi Characterized by Macular versus Papular Speckles

Cruz

Happle²

2006

Dermatology

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Background: Speckled lentiginous nevus (SLN; synonym: nevus spilus) is a darkly spotted light-brown macule that mostly occurs as an isolated lesion of rather limited dimensions but sometimes may involve large areas of the body. So far, this skin disorder has been considered to represent one clinical entity. Objective: Because SLN is occasionally associated with complex birth defects such as phacomatosis pigmentovascularis, phacomatosis pigmentokeratotica, or SLN syndrome, we tested our idea that two different types of SLN may exist, each one associated with a particular syndrome. Methods: A review of case reports on SLN published during the years 1970–2004 was performed. Results: This evaluation of cases provided evidence that two different types of SLN exist, in the form of macular versus papular SLN, each one being related to a specific syndrome. Macular SLN is characterized by a tannish-brown background with darker flat speckles. The distribution of speckles is rather even and resembles a polka-dot pattern. Histopathologically, this type of SLN is characterized by what has been called a ‘jentigo’ pattern in the darker speckles and by some nests of melanocytes at the dermoepidermal junction at the tips of the papillae, whereas the background pigmentation shows the microscopical features of a lentigo. Papular SLN is characterized by a light-brown macule superimposed by multiple melanocytic nevi in the form of papules or nodules that show a more uneven distribution reminiscent of a star map. Small dark macules may likewise be present. Histopathologically, the papular component consists of dermal or compound melanocytic nevi. A separation of the two types of SLN is important because our analysis showed that macular SLN is a hallmark of a particular type of phacomatosis pigmentovascularis, whereas papular SLN is typically present in phacomatosis pigmentokeratotica as well as in SLN syndrome. Conclusions: Macular SLN and papular SLN appear to be two distinct cutaneous entities. This dichotomy may turn out to be important when such nevi will be analyzed at the molecular level.

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Frequency of Congenital Nevi, Nevi spili and Café-au-Lait Spots and Their Relation to Nevus Count and Skin Complexion in 939 Children

Cited by 61 publications

References 11 publications

The dermatological spectrum of Turner syndrome

The dermatological spectrum of Turner syndrome

Classification and Prevalence of Pigmented Lesions in Patients with Total-Body Photographs at High Risk of Developing Melanoma

Two Distinct Types of Speckled Lentiginous Nevi Characterized by Macular versus Papular Speckles

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