Liver disease was common in adults with CF but disease progression was rare. Thus liver disease detected and closely monitored in adults appeared to have a milder course than childhood CF. Splenomegaly, unrelated to portal hypertension may be a consequence of CF.
(Cambridge, UK). His laboratory, funded by the Wellcome Trust and Medical Research Council (UK), is focussed on understanding how the immune system interacts with bacterial and mycobacterial pathogens to trigger inflammatory lung damage. He is head of research at the Cambridge Centre for Lung Infection directing clinical and translational studies on CF and non-CF bronchiectasis and is an Honorary Consultant at Papworth Hospital and Addenbrooke's Hospital (both Cambridge). Recent honours received include the BUPA Foundation Researcher of the Year award (2010) and the European Respiratory Society Maurizio Vignola Award for Innovation in Pulmonology (2007).
The aim of the study was to evaluate the impact of manual cleaning and manual cleaning followed by Ultraviolet-C disinfection on the colony forming units of bacteria retrievable from equipment and surfaces within clinic rooms following a CF outpatient encounter. While UV disinfection has proven to be effective within general healthcare settings, it has not been evaluated in a CF centre. Microbiological sampling was performed following outpatient encounters involving 11 adult patients with CF and chronic infection with P.aeruginosa, MRSA or E. coli ESBL. The results of this study suggest that manual cleaning followed by UV-C disinfection is more effective than manual cleaning alone at reducing environmental contamination within a CF clinic and that UV-C isinfection is likely to reduce the risk of fomite transmission in the CF outpatient setting.
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