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This study describes the effect of several inducing-agents on drug metabolism in Sprague-Dawley and Long-Evans rats. DDT, eucalyptol, and phenobarbital are less active in Long-Evans than in Sprague-Dawley rats. 3-Methylchol-anthrene, on the other hand, induces drug metabolism at similar extent in both strains. Experiments with phenobarbital show that the reduced reactivity of Long-Evans rats is dependent neither on the plasma and liver concentration of the inducing agent nor on time. However, a different reactivity to phenobarbital induction has been demonstrated in Long-Evans of 2 different sources.

Diazepam and chlordiazepoxide, even at high single doses, do not inhibit the metabolic transformation of p‐nitroanisol, aniline and aminopyrine by the 9,000 g fraction of rat liver. Although diazepam and chlordiazepoxide increase the sleeping time induced by pentobarbitone, this effect is not explained by an increase in the brain level of pentobarbitone. Repeated administrations of the two benzodiazepines increase the metabolism of p‐nitroanisol, aniline, amidopyrine and shorten the sleeping time induced by pentobarbitone in rats. There was a concomitant reduction of the concentration of brain pentobarbitone.