Aim-To investigate overexpression of cerbB2, expression ofthe p53 protein product and proliferation rates in benign breast lesions with specific reference to apocrine adenosis. Methods-Twenty one cases of apocrine adenosis were stained with monoclonal antibodies to p185, the protein product of the c-erbB2 oncogene, the protein product of the p53 tumour suppressor gene and to the cell cycle related protein Ki67. Three cases were associated with concomitant ductal carcinoma in situ of large cell type and two were associated with invasive tubular or cribriform carcinoma. Results-Twelve (57.1%) cases showed membrane staining for c-erbB2 oncoprotein of apocrine cells within sclerosing adenosis and six (28.6%) had occasional p53 protein positive cells. One case not associated with carcinoma showed extensive staining of apocrine metaplasia outside the area of apocrine adenosis. The proliferation rate, as measured by Ki67 staining, was increased in some of the lesions and all lesions showed at least some of the cells to be in the cell cycle. Conclusions-The expression ofabnormal oncogene products and increased proliferation in some ofthese apocrine lesions questions the supposed degenerative nature of the atypia seen in such cases and suggests that there may be an association between these lesions and large cell ductal carcinoma in situ and hence invasive carcinoma. (J Clin Pathol 1995;48:737-742)
✓ The authors present the case of spinal cord compression in a 16-year-old boy due to the rare vascular lesion, Masson's vegetant hemangioendothelioma.
A case of papillary tubular adenoma of the skin in a 31-year-old black man is reported. This lesion is also termed papillary eccrine adenoma, and it commonly occurs in the extremities.
Background Notalgia paraesthelica is an uncommon sensory neuropathy of unknown aetiology that appears to be mediated by peptidergic nerves.Objective To investigate both functional and anatomical aspects of notalgia paraesthetica using laser Doppler veiocimetry and immunohistoehemistry and to assess the effect of treatment on these parameters.Metbods Basal blood flow and response to local heating were recorded in 7 patients with notalgia paraesthetica from within the affected area and the contralateral side as control. Biopsies were taken from both sites for immunohistoehemistry with SIOO protein. PGP9.5 and CDla. Measurements were repeated after treatment with topical capsaicin.Results All patients benefited from capsaicin treatment suggesting that the symptoms of notalgia paraesthetica are mediated by peptidergic sensory nerves. Basal blood tlow and response to local heating were generally reduced in the affected areas prior to treatment but this did not achieve statistical significance. These differences were less obvious following treatment. The density of CDla immunoreactive epidermal Langerhans cells and small nerve fibres in the upper dermis both appeared to be slightly increased in the majority of patients within the affected area. No significant change was noted in 3 patients who were rebiopsied after treatment.Conclusions We conclude that in notalgia paraesthetica there is a localised functional abnormality of peptidergic sensory nerves. The relevance of the subtle histological findings is unclear. S0926-9959(94)0()070-0 S.M. Hatpetn ct ai/J. Etir. Acad. Dermatoi Venereoi 7 (1996) 22H-234 229
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