Papillary Tubular Adenoma of the Skin

Makunura, C. N.

doi:10.1111/j.1346-8138.1993.tb01398.x

Cited by 6 publications

(5 citation statements)

References 5 publications

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“…In the present case, many a-SMA-positive myoepithelial cells were found at the outermost layer of the tubular structure. Moreover, the staining of the a-SMApositive cells with keratin 14 confirmed the cells to 15 16 17 present case ND, not described be myoepithelial cells, and positivity for keratin 8 of the inner layer cells suggests that the antigen expression is comparable to light and dark cells of the eccrine secretory coil; these immunohistochemical results strongly stiggest the tumor to be of eccrine coil origin. Table 2 describes the cases of papillary eccrine adenoma reported in the literatvtre.…”

Section: Discussionsupporting

confidence: 73%

“…Papillary eccrine adenoma, first described by Rulon and Helwig in 1977 (1), is a rare cutaneous tumor. Only 36 cases have been reported in tlie English literature (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). The ttimor presents as a solitary cutaneous nodule, localized in the dermis, and is characterized by numerous dilated tubules lined by a double layer of cells with intrahiminal papillary projections surrounded by fibrous stroma (1).…”

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confidence: 99%

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Papillary eccrine adenoma: Immunohistochemicai study and literature review

et al. 1998

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A case of papillary eccrine adenoma on the right forearm of a 78-year-old Japanese woman is reported. The tumor was 1.3 cm in diameter, occupying the whole thickness of the dermis. Histologically, the tumor was composed of dilated tubules of various sizes with intraluminal papillary projections, and was surrounded by a fibrous stroma. An immunohistochemical study revealed that the proliferating tubules were composed of a single outermost layer of alpha-smooth muscle actin- and keratin 14-positive myoepithelial cells, and keratin 8-positive inner cells. This antigen expression pattern was comparable to that of the normal eccrine secretory coil, which indicates that the tumor differentiated toward the secretory coil of an eccrine sweat gland.

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Section: Discussionsupporting

confidence: 73%

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confidence: 99%

Papillary eccrine adenoma: Immunohistochemicai study and literature review

et al. 1998

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“…The fibrous stroma around the lesion is well separated from the surrounding dermis. The tumour cells give a positive reaction to carcinoembryonic antigen, S‐100 protein, EMA and GCDFP‐15 …”

Section: Discussionmentioning

confidence: 99%

“…The tumour cells give a positive reaction to carcinoembryonic antigen, S-100 protein, EMA and GCDFP-15. 4 The differential diagnosis in cases with this presentation includes other cutaneous neoplasms with intraductal papillary proliferation, including apocrine hidrocystoma, apocrine cystadenoma, apocrine gland carcinoma and especially, papillary eccrine adenoma (PEA). PEA is a benign neoplasm of sweat gland origin.…”

Section: Discussionmentioning

confidence: 99%

An asymptomatic nodule on the forearm

Topal

Sakiz

et al. 2014

Clin Exp Dermatol

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A 53-year-old woman presented with a solitary lesion on her left forearm, which had first appeared approximately 20 years earlier and had gradually increased in size. Physical examination (Fig. 1) revealed a firm, reddish-brown, dome-shaped nodule, 30 9 20 mm in diameter. In addition, there were yellow-brown, circular crusts of around 1 mm in size over the lesion, along with a bleeding ulcerative area. Histopathological findingsOn histological examination of a skin biopsy specimen, hyperkeratosis, light acanthosis and focal basaloid cell proliferation were seen in the epidermis. In the dermis, there were cystic dilated and branching tubular structures with papillary projections into the lumen, surrounded by a fibrous stroma. These ducts were surrounded by two layers of epithelial cells. The ductal cells were primarily cuboidal, but some were columnar and/or flattened. The cuboidal cells of the inner layer of the tubular structures showed decapitation secretion (Fig. 2a,b) and were positive for epithelial membrane antigen (EMA) and gross cystic disease fluid protein (GCDFP)-15 (Fig. 2c,d).

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“…Dermatoscopic features include milia-like cysts, ulcerations, and arborizing, hairpin, glomerular vessels [ 264 ]. Immunohistochemical findings include CEA and EMA (luminal cells of tubules) and S100, p63, and calponin with SMA (outer cell layer) [ 189 , 262 , 265 , 266 , 267 ].…”

Section: Tumors With Apocrine and Eccrine Differentiationmentioning

confidence: 99%

Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation

Płachta

Kleibert

Czarnecka

et al. 2021

IJMS

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Adnexal tumors of the skin are a rare group of benign and malignant neoplasms that exhibit morphological differentiation toward one or more of the adnexal epithelium types present in normal skin. Tumors deriving from apocrine or eccrine glands are highly heterogeneous and represent various histological entities. Macroscopic and dermatoscopic features of these tumors are unspecific; therefore, a specialized pathological examination is required to correctly diagnose patients. Limited treatment guidelines of adnexal tumor cases are available; thus, therapy is still challenging. Patients should be referred to high-volume skin cancer centers to receive an appropriate multidisciplinary treatment, affecting their outcome. The purpose of this review is to summarize currently available data on pathogenesis, diagnosis, and treatment approach for apocrine and eccrine tumors.

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Papillary Tubular Adenoma of the Skin

Abstract: A case of papillary tubular adenoma of the skin in a 31-year-old black man is reported. This lesion is also termed papillary eccrine adenoma, and it commonly occurs in the extremities.

Cited by 6 publications

References 5 publications

Papillary eccrine adenoma: Immunohistochemicai study and literature review

Papillary eccrine adenoma: Immunohistochemicai study and literature review

An asymptomatic nodule on the forearm

Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation

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