6 minutes after Joduron | 70% (0.5 ml/kg), Biligrafin | 30% (0.4 ml/kg), Urografin | 60% (0.5 ml/kg), Urovison | 58% (0.5 ml/kg), Urovist | 65% (0.75 ml/kg) and Conray | 70% (0.5 ml/kg) (within 1 minute injected) the level of circulating histamine in plasma is increased from less than 1.0 ng/ml to 2.0-2.5 ng/ml. The elevated levels return to normal within 20 minutes, in the case of Joduron | 70% and Biligrafin | 30% slower than after the other contrast media. Urivison | 30%, infused over 4 minutes (total dose 4 ml/kg), as dextrose 50%-solution (0.5 ml/kg) failed to change histamine concentration in plasma. Obviously the histamine liberating effect of the contrast media is a specific effect of these agents.
Daring open-heart surgery with extracorporeal circulation, platelets lose serotonin while taking up histamine. Thus, platelets may be involved in the elimination of increased histamine plasma levels. The storage mechanisms for serotonin and histamine in platelets seem to function independently.
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