Clinical Therapeutics e94Volume 35 Number 8SResults: A significant increase (P < 0.05) in feed consumption, body weight gain, relative weights of testis and epididymis and intratesticular cholesterol level, follicle stimulating hormone (FSH), luteinizing hormone (LH), and prolactin was found in rats received dimethoate.On the other side, a significant decrease (P < 0.05) in absolute weight of testes and epididymis, serum cholesterol and testosterone levels, serum acetylcholine esterase (AChE) activity ,total sperm count, motility and fertility index was observed compared with the control group. Histopathologic results also indicated enlargement of interstitial space, inhibition of spermatogenesis, and variable degrees of degenerative changes in the seminiferous tubules up to total cellular destruction.
Conclusion:Our results proved that dimethoate, could act as neuroendocrine disruptor via inhibition of AChE activity and increase of acetylcholine level in brain. This effect might be linked to the suppression of the brain's release of hormones that stimulate the gonadotrophic hormones (LH and FSH). So we have to be aware that dimethoate has detrimental effects on the male rat reproductive system.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.