Antibacterial activities of Coptis chinensis and Glycyrrhiza glabra against seven bacteria associated with human gastrointestinal infections

Mekseepralard, C.; Poonpon, P.; Kamkaen, Narisa

doi:10.1055/s-2007-986921

Cited by 1 publication

(1 citation statement)

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“…However, the potential side effects of SC on the gut microbiota cannot be ignored. It has been found that Scutellaria and Coptis both have remarkable antibacterial effects [ 51 , 52 ], and in this study, the total amount and diversity of the gut microbiota were significantly inhibited in the SC intervention groups; at the same time, the abundance levels of some beneficial genera, such as Lactobacillus , were also markedly reduced. Therefore, the effect of SC on the gut microbiota was multidimensional, as it could not only inhibit harmful bacteria but also destroy the normal structure of the intestinal flora.…”

Section: Discussionsupporting

confidence: 56%

The Herbal Medicine Scutellaria-Coptis Alleviates Intestinal Mucosal Barrier Damage in Diabetic Rats by Inhibiting Inflammation and Modulating the Gut Microbiota

Zhang

Yue

Chen

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Recent studies have confirmed that increased intestinal permeability and gut-origin lipopolysaccharide (LPS) translocation are important causes of metabolic inflammation in type 2 diabetes (T2D), but there are no recognized therapies for targeting this pathological state. Scutellaria baicalensis and Coptis chinensis are a classic herbal pair often used to treat diabetes and various intestinal diseases, and repair of intestinal barrier damage may be at the core of their therapeutic mechanism. This study investigated the effects of oral administration of Scutellaria-Coptis (SC) on the intestinal mucosal barrier in diabetic rats and explored the underlying mechanism from the perspective of anti-inflammatory and gut microbiota-modulatory effects. The main results showed that, in addition to regulating glycolipid metabolism disorders and inhibiting serum inflammatory factors, SC could also upregulate the expression levels of the tight junction proteins claudin-1, occludin, and zonula occludens (ZO-1), significantly improve intestinal epithelial damage, and inhibit excessive LPS translocation into the blood circulation. Furthermore, it was found that SC could reduce the levels of the inflammatory factors interleukin-1β (IL-1β), IL-6, and tumour necrosis factor-α (TNF-α) in intestinal tissue and that the anti-inflammatory effects involved the TLR-4/TRIF and TNFR-1/NF-κB signalling pathways. Moreover, SC had a strong inhibitory effect on some potential enteropathogenic bacteria and LPS-producing bacteria, such as Proteobacteria, Enterobacteriaceae, Enterobacter, Escherichia-Shigella, and Enterococcus, and could also promote the proliferation of butyrate-producing bacteria, such as Lachnospiraceae and Prevotellaceae. Taken together, the hypoglycaemic effects of SC were related to the protection of the intestinal mucosal barrier, and the mechanisms might be related to the inhibition of intestinal inflammation and the regulation of the gut microbiota.

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Section: Discussionsupporting

confidence: 56%