As buckwheat honey was most effective in reducing ROS levels, it was selected for use in wound-healing products. The major antioxidant properties in buckwheat honey derive from its phenolic constituents, which are present in relatively large amounts. Its phenolic compounds may also exert antibacterial activity, whereas its low pH and high free acid content may assist wound healing.
From the latex of Jatropha curcas L. (Euphorbiaceae) a novel cyclic octapeptide was isolated, which we named curcacycline A. The compound was found to contain one threonine, one valine, two glycine, and four leucine residues. By two-dimensional ~H-NMR spectroscopy (HOHAHA and ROESY), its sequence was determined to be GiyLLeu2-Leu3-Gly4-ThrS-Val6-LeuT-Leu sGly% Curcacycline A displays a moderate inhibition of (i) classical pathway activity of human complement and (ii) proliferation of human T-cells.and two-dimensional 1H-NMR spectroscopy (HOHAHA and ROESY).
Experimental
Plant materialJatropha curcas L. plants grown as hedges in Jepara (near Kudus, Java, Indonesia) were identified. Crude latex was obtained by cutting off leaf stalks, adding a few drops of EtOH to prevent the latex from excessive foaming. The latex was stored at -20°C until use.
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